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<identifier>oai:HAL:hal-01668322v1</identifier>
<datestamp>2018-01-04</datestamp>
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<setSpec>subject:sdv</setSpec>
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<publisher>HAL CCSD</publisher>
<title lang=en>Differences of microparticle patterns between sickle cell anemia and hemoglobin SC patients</title>
<creator>Garnier, Yohann</creator>
<creator>Ferdinand, Séverine</creator>
<creator>Etienne-Julan, Maryse</creator>
<creator>Elana, Gisèle</creator>
<creator>Petras, Marie</creator>
<creator>Doumdo, Lydia</creator>
<creator>Tressieres, Benoît</creator>
<creator>Lalanne-Mistrih, Marie-Laure</creator>
<creator>Hardy-Dessources, Marie-Dominique</creator>
<creator>Connes, Philippe</creator>
<creator>Romana, Marc</creator>
<contributor>Biologie Intégrée du Globule Rouge ; Institut National de la Transfusion Sanguine [Paris] (INTS) - Université Paris Diderot - Paris 7 (UPD7) - Université de la Réunion (UR) - Institut National de la Santé et de la Recherche Médicale (INSERM) - CHU de Pointe-à-Pitre</contributor>
<contributor>Observatoire Régional de la Santé de la Guadeloupe ; Observatoire Régional de la Santé de la Guadeloupe</contributor>
<contributor>Unité Transversale de la Drépanocytose ; CHU Pointe-à-Pitre/Abymes</contributor>
<contributor>CHU Fort de France</contributor>
<contributor>Centre d'Investigation Clinique Antilles-Guyane (CIC - Antilles Guyane) ; Université des Antilles et de la Guyane (UAG) - Institut National de la Santé et de la Recherche Médicale (INSERM) - CHU de Pointe-à-Pitre - Centre Hospitalier de Cayenne Andrée Rosemon - CHU de Fort de France</contributor>
<contributor>Centre d'investigation clinique Antilles-Guyane ; Institut National de la Santé et de la Recherche Médicale (INSERM) - CH Cayenne</contributor>
<contributor>Dynamique des Structures et Interactions des Macromolécules Biologiques- Pôle de La Réunion (DSIMB Réunion) ; Dynamique des Structures et Interactions des Macromolécules Biologiques (DSIMB) ; Institut National de la Transfusion Sanguine [Paris] (INTS) - Université Paris Diderot - Paris 7 (UPD7) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Institut National de la Transfusion Sanguine [Paris] (INTS) - Université Paris Diderot - Paris 7 (UPD7) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Université de la Réunion (UR)</contributor>
<description>International audience</description>
<source>ISSN: 1932-6203</source>
<source>PLoS ONE</source>
<publisher>Public Library of Science</publisher>
<identifier>hal-01668322</identifier>
<identifier>https://hal.univ-antilles.fr/hal-01668322</identifier>
<identifier>https://hal.univ-antilles.fr/hal-01668322/document</identifier>
<identifier>https://hal.univ-antilles.fr/hal-01668322/file/journal.pone.0177397.pdf</identifier>
<source>https://hal.univ-antilles.fr/hal-01668322</source>
<source>PLoS ONE, Public Library of Science, 2017, 12 (5), pp.e0177397. 〈10.1371/journal.pone.0177397〉</source>
<identifier>DOI : 10.1371/journal.pone.0177397</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pone.0177397</relation>
<language>en</language>
<subject>[SDV.MHEP.HEM] Life Sciences [q-bio]/Human health and pathology/Hematology</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>Sickle cell anemia (SCA) and hemoglobin SC (HbSC) disease are the two most common forms of sickle cell disease (SCD), a frequent hemoglobinopathy which exhibits a highly variable clinical course. Although high levels of microparticles (MPs) have been consistently reported in SCA and evidence of their harmful impact on the SCA complication occurrences have been provided, no data on MP pattern in HbSC patients has been reported so far. In this study, we determined and compared the MP patterns of 84 HbSC and 96 SCA children, all at steady-state, using flow cytometry. Most of circulating MPs were derived from platelets (PLTs) and red blood cells (RBCs) in the two SCD syndromes. Moreover, we showed that HbSC patients exhibited lower blood concentration of total MPs compared to SCA patients, resulting mainly from a decrease of MP levels originated from RBCs and to a lesser extent from PLTs. We did not detect any association between blood MP concentrations and the occurrence of painful vaso-occlusive crises, acute chest syndrome and pulmonary hyper-tension in both patient groups. We also demonstrated for the first time, that whatever the considered genotype, RBC-derived MPs exhibited higher externalized phosphatidylserine level and were larger than PLT-derived MPs.</description>
<date>2017</date>
</dc>
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