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<datestamp>2017-12-21</datestamp>
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<title lang=en>Drawing a Waddington landscape to capture dynamic epigenetics.</title>
<title lang=en>Drawing a Waddington landscape to capture dynamic epigenetics. : Draw me a landscape</title>
<creator>Nicol-Benoit, Floriane</creator>
<creator>Le Goff, Pascale</creator>
<creator>Michel, Denis</creator>
<contributor>Institut de recherche, santé, environnement et travail [Rennes] (Irset) ; Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )</contributor>
<contributor>TREC : Transcription, Environment and Cancer ; Institut de recherche, santé, environnement et travail [Rennes] (Irset) ; Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ) - Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )</contributor>
<description>International audience</description>
<source>ISSN: 0248-4900</source>
<source>EISSN: 1768-322X</source>
<source>Biology of the Cell</source>
<publisher>Wiley</publisher>
<identifier>inserm-00920766</identifier>
<identifier>http://www.hal.inserm.fr/inserm-00920766</identifier>
<identifier>http://www.hal.inserm.fr/inserm-00920766/document</identifier>
<identifier>http://www.hal.inserm.fr/inserm-00920766/file/Dynamic_Epigenetics.pdf</identifier>
<source>http://www.hal.inserm.fr/inserm-00920766</source>
<source>Biology of the Cell, Wiley, 2013, 105 (12), pp.576-84. 〈10.1111/boc.201300029〉</source>
<identifier>PUBMED : 24111561</identifier>
<relation>info:eu-repo/semantics/altIdentifier/pmid/24111561</relation>
<identifier>DOI : 10.1111/boc.201300029</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1111/boc.201300029</relation>
<language>en</language>
<subject lang=en>epigenetics</subject>
<subject lang=en>multi-stability</subject>
<subject lang=en>steady state</subject>
<subject>[SDV.GEN] Life Sciences [q-bio]/Genetics</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>Epigenetics is most often reduced to chromatin marking in the current literature, whereas this notion was initially defined in a more general context. This restricted view ignores that epigenetic memories are in fact more robustly ensured in living systems by steady-state mechanisms with permanent molecule renewal. This misconception is likely to result from misleading intuitions and insufficient dialogues between traditional and quantitative biologists. To demystify dynamic epigenetics, its most famous image, a Waddington landscape and its attractors, are explicitly drawn. The simple example provided, is sufficient to highlight the main requirements and characteristics of dynamic gene networks, underlying cellular differentiation, de-differentiation and trans-differentiation.</description>
<date>2013-12</date>
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