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<title lang=en>Drinking water disinfection by-products, genetic polymorphisms, and birth outcomes in a european mother-child cohort study</title>
<creator>Kogevinas, M.</creator>
<creator>Bustamante, M.</creator>
<creator>Gracia-Lavedán, E.</creator>
<creator>Ballester, F.</creator>
<creator>Cordier, S.</creator>
<creator>Costet, N.</creator>
<creator>Espinosa, A.</creator>
<creator>Grazuleviciene, R.</creator>
<creator>Danileviciute, A.</creator>
<creator>Ibarluzea, J.</creator>
<creator>Karadanelli, M.</creator>
<creator>Krasner, S.</creator>
<creator>Patelarou, E.</creator>
<creator>Stephanou, E.</creator>
<creator>Tardón, A.</creator>
<creator>Toledano, M.B.</creator>
<creator>Wright, J.</creator>
<creator>Villanueva, C.M.</creator>
<creator>Nieuwenhuijsen, M.</creator>
<contributor>Center for Research in Environmental Epidemiology (CREAL) ; Universitat Pompeu Fabra [Barcelona] - Catalunya ministerio de salud</contributor>
<contributor>Center for Public Health Research (CSISP) ; University of Valencia</contributor>
<contributor>Institut des Sciences Chimiques de Rennes (ISCR) ; Université de Rennes 1 (UR1) - Ecole Nationale Supérieure de Chimie de Rennes - Institut National des Sciences Appliquées (INSA) - Centre National de la Recherche Scientifique (CNRS)</contributor>
<contributor>Institut de recherche, santé, environnement et travail [Rennes] (Irset) ; Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )</contributor>
<contributor>Matière et Systèmes Complexes (MSC) ; Université Paris Diderot - Paris 7 (UPD7) - Centre National de la Recherche Scientifique (CNRS)</contributor>
<contributor>Vytautas Magnus University ; Vytautas Magnus University</contributor>
<description>International audience</description>
<source>Epidemiology</source>
<identifier>hal-01392115</identifier>
<identifier>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01392115</identifier>
<source>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01392115</source>
<source>Epidemiology, 2016, 27 (6), pp.903--911. 〈10.1097/EDE.0000000000000544〉</source>
<identifier>DOI : 10.1097/EDE.0000000000000544</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1097/EDE.0000000000000544</relation>
<identifier>PUBMED : 27468006</identifier>
<relation>info:eu-repo/semantics/altIdentifier/pmid/27468006</relation>
<language>en</language>
<subject>[SDV.EE.SANT] Life Sciences [q-bio]/Ecology, environment/Health</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>Background: We examined the association between exposure during pregnancy to trihalomethanes, the most common water disinfection by-products, and birth outcomes in a European cohort study (Health Impacts of Long-Term Exposure to Disinfection By-Products in Drinking Water). We took into account exposure through different water uses, measures of water toxicity, and genetic susceptibility. Methods: We enrolled 14,005 mothers (2002-2010) and their children from France, Greece, Lithuania, Spain, and the UK. Information on lifestyle- and water-related activities was recorded. We ascertained residential concentrations of trihalomethanes through regulatory records and ad hoc sampling campaigns and estimated route-specific trihalomethane uptake by trimester and for whole pregnancy. We examined single nucleotide polymorphisms and copy number variants in disinfection by-product metabolizing genes in nested case-control studies. Results: Average levels of trihalomethanes ranged from around 10 μg/L to above the regulatory limits in the EU of 100 μg/L between centers. There was no association between birth weight and total trihalomethane exposure during pregnancy (β = 2.2 g in birth weight per 10 μg/L of trihalomethane, 95% confidence interval = 3.3, 7.6). Birth weight was not associated with exposure through different routes or with specific trihalomethane species. Exposure to trihalomethanes was not associated with low birth weight (odds ratio [OR] per 10 μg/L = 1.02, 95% confidence interval = 0.95, 1.10), small-for-gestational age (OR = 0.99, 0.94, 1.03) and preterm births (OR = 0.98, 0.9, 1.05). We found no gene-environment interactions for mother or child polymorphisms in relation to preterm birth or small-for-gestational age. Conclusions: In this large European study, we found no association between birth outcomes and trihalomethane exposures during pregnancy in the total population or in potentially genetically susceptible subgroups. © 2016 Wolters Kluwer Health, Inc.</description>
<date>2016</date>
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