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<identifier>oai:HAL:hal-01668320v1</identifier>
<datestamp>2018-01-04</datestamp>
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<title lang=en>Decrease of externalized phosphatidylserine density on red blood cell-derived microparticles in SCA patients treated with hydroxycarbamide</title>
<creator>Garnier, Yohann</creator>
<creator>Ferdinand, Séverine</creator>
<creator>Connes, Philippe</creator>
<creator>Garnier, Marie</creator>
<creator>Etienne-Julan, Maryse</creator>
<creator>Lemonne, Nathalie</creator>
<creator>Romana, Marc</creator>
<contributor>Biologie Intégrée du Globule Rouge ; Institut National de la Transfusion Sanguine [Paris] (INTS) - Université Paris Diderot - Paris 7 (UPD7) - Université de la Réunion (UR) - Institut National de la Santé et de la Recherche Médicale (INSERM) - CHU de Pointe-à-Pitre</contributor>
<contributor>Observatoire Régional de la Santé de la Guadeloupe ; Observatoire Régional de la Santé de la Guadeloupe</contributor>
<contributor>Dynamique des Structures et Interactions des Macromolécules Biologiques- Pôle de La Réunion (DSIMB Réunion) ; Dynamique des Structures et Interactions des Macromolécules Biologiques (DSIMB) ; Institut National de la Transfusion Sanguine [Paris] (INTS) - Université Paris Diderot - Paris 7 (UPD7) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Institut National de la Transfusion Sanguine [Paris] (INTS) - Université Paris Diderot - Paris 7 (UPD7) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Université de la Réunion (UR)</contributor>
<contributor>Centre de recherche Cultures anglo-saxonnes (CAS) ; Université Toulouse 2 (UT2)</contributor>
<contributor>Unité Transversale de la Drépanocytose ; CHU Pointe-à-Pitre/Abymes</contributor>
<contributor>Protéines de la membrane érythrocytaire et homologues non-érythroides ; Université des Antilles et de la Guyane (UAG) - Institut National de la Transfusion Sanguine [Paris] (INTS) - Université Paris Diderot - Paris 7 (UPD7) - Université de la Réunion (UR) - Institut National de la Santé et de la Recherche Médicale (INSERM)</contributor>
<description>International audience</description>
<source>ISSN: 0007-1048</source>
<source>EISSN: 1365-2141</source>
<source>British Journal of Haematology</source>
<publisher>Wiley</publisher>
<identifier>hal-01668320</identifier>
<identifier>https://hal.univ-antilles.fr/hal-01668320</identifier>
<identifier>https://hal.univ-antilles.fr/hal-01668320/document</identifier>
<identifier>https://hal.univ-antilles.fr/hal-01668320/file/Garnier%20et%20al%20BJH-2017-00655.pdf</identifier>
<source>https://hal.univ-antilles.fr/hal-01668320</source>
<source>British Journal of Haematology, Wiley, A Paraître, 〈10.1111/bjh.14810〉</source>
<identifier>DOI : 10.1111/bjh.14810</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1111/bjh.14810</relation>
<language>en</language>
<subject lang=en>phosphatidylserine</subject>
<subject lang=en>microparticles</subject>
<subject lang=en>red blood cell</subject>
<subject lang=en>hydroxycarbamide</subject>
<subject lang=en>sickle cell anaemia</subject>
<subject>[SDV.MHEP.HEM] Life Sciences [q-bio]/Human health and pathology/Hematology</subject>
<subject>[SDV.SP.MED] Life Sciences [q-bio]/Pharmaceutical sciences/Medication</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>Hydroxycarbamide (HC) treatment has been shown to improve the clinical course of patients with sickle cell anaemia (SCA), a haemoglobinopathy resulting from a single base substitution in the bêta-globin gene (HBB). SCA is characterized by chronic haemolytic anaemia and recurrent vascular occlusions leading to multisystemic complications. Several beneficial biological effects of HC have been documented (Halsey et al, 2003) but its impact on the concentration of circulating microparticles (MPs), a subtype of extracellular vesicles released from cytoplasmic membrane of activated or apoptotic cells and detected at high levels in sickle plasma, remains controversial (Hebbel et al, 2016). The aim of the present study was to compare the MP pattern in a group of SCA patients treated by HC and followed for 2 years. </description>
<date>2017</date>
</dc>
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