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<title lang=en>Dynamic ER Interactomes Control the Estrogen-Responsive Trefoil Factor (TFF) Locus Cell-Specific Activities.</title>
<creator>Quintin, Justine</creator>
<creator>Le Péron, Christine</creator>
<creator>Palierne, Gaëlle</creator>
<creator>Bizot, Maud</creator>
<creator>Cunha, Stéphanie</creator>
<creator>Sérandour, Aurélien A</creator>
<creator>Avner, Stéphane</creator>
<creator>Henry, Catherine</creator>
<creator>Percevault, Frédéric</creator>
<creator>Belaud-Rotureau, Marc-Antoine</creator>
<creator>Huet, Sébastien</creator>
<creator>Watrin, Erwan</creator>
<creator>Eeckhoute, Jérôme</creator>
<creator>Legagneux, Vincent</creator>
<creator>Salbert, Gilles</creator>
<creator>Métivier, Raphaël</creator>
<contributor>Interactions cellulaires et moléculaires (ICM) ; Université de Rennes 1 (UR1) - IFR140 - Centre National de la Recherche Scientifique (CNRS)</contributor>
<contributor>Institut de Génétique et Développement de Rennes (IGDR) ; Université de Rennes 1 (UR1) - Centre National de la Recherche Scientifique (CNRS) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )</contributor>
<contributor>Cancer Research UK Cambridge Institute ; University of Cambridge [UK] (CAM)</contributor>
<contributor>Service de Cytogénétique et de Biologie Cellulaire ; Université de Rennes 1 (UR1) - Hôpital Pontchaillou - CHU Pontchaillou [Rennes]</contributor>
<contributor>Institut de recherche, santé, environnement et travail [Rennes] (Irset) ; Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )</contributor>
<contributor>European Molecular Biology Laboratory [Heidelberg] (EMBL)</contributor>
<contributor>Récepteurs nucléaires, maladies cardiovasculaires et diabète EGID FR 3508 ; Institut Pasteur de Lille - Institut National de la Santé et de la Recherche Médicale (INSERM) - Université de Lille, Droit et Santé</contributor>
<contributor>Institut de Génétique et Développement de Rennes (IGDR) ; Université de Rennes 1 (UR1) - IFR140 - Centre National de la Recherche Scientifique (CNRS)</contributor>
<description>International audience</description>
<source>ISSN: 0270-7306</source>
<source>Molecular and Cellular Biology</source>
<publisher>American Society for Microbiology</publisher>
<identifier>hal-00984591</identifier>
<identifier>https://hal-univ-rennes1.archives-ouvertes.fr/hal-00984591</identifier>
<identifier>https://hal-univ-rennes1.archives-ouvertes.fr/hal-00984591/document</identifier>
<identifier>https://hal-univ-rennes1.archives-ouvertes.fr/hal-00984591/file/Mol._Cell._Biol.-2014-Quintin-MCB.00918-13.pdf</identifier>
<source>https://hal-univ-rennes1.archives-ouvertes.fr/hal-00984591</source>
<source>Molecular and Cellular Biology, American Society for Microbiology, 2014, 34 (13), pp.2418-2436. 〈10.1128/MCB.00918-13〉</source>
<identifier>DOI : 10.1128/MCB.00918-13</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1128/MCB.00918-13</relation>
<identifier>PUBMED : 24752895</identifier>
<relation>info:eu-repo/semantics/altIdentifier/pmid/24752895</relation>
<language>en</language>
<subject>[SDV.BBM.BM] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>: Estradiol signaling is ideally suited for analyzing molecular and functional linkages between the different layers of information directing transcriptional regulations: DNA sequence, chromatin modifications and the spatial organization of the genome. Hence, estrogen receptor (ER) can bind at a distance from its target genes and engages timely and spatially coordinated processes to regulate their expression. In the context of the coordinated regulations of co-linear genes, identifying which ER binding sites (ERBSs) regulate a given gene still remains a challenging question. Here, we investigated the coordination of such regulatory events at a 2 Mb genomic locus containing the estrogen-sensitive TFF cluster of genes in breast cancer cells. We demonstrated that this locus exhibits a hormone and cohesin-dependent reduction in the plasticity of its three-dimensional organization that allows multiple ERBSs to be dynamically brought to the vicinity of estrogen-sensitive genes. Additionally, by using triplex forming oligonucleotides, we could precisely document the functional links between ER engagement at given ERBSs and the regulation of particular genes. Hence, our data evidence a formerly suggested cooperation of enhancers towards gene regulations, and also show that redundancy between ERBSs can occur.</description>
<date>2014-04-21</date>
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