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<datestamp>2018-01-11</datestamp>
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<publisher>HAL CCSD</publisher>
<title lang=en>Global and local environmental changes as drivers of Buruli ulcer emergence</title>
<creator>Combe, Marine</creator>
<creator>Velvin, Camilla Jensen</creator>
<creator>Morris, Aaron</creator>
<creator>Garchitorena, Andres</creator>
<creator>Carolan, Kevin</creator>
<creator>Sanhueza, Daniel</creator>
<creator>Roche, Benjamin</creator>
<creator>Couppié, Pierre</creator>
<creator>Guégan, Jean-François</creator>
<creator>Gozlan, Rodolphe Elie</creator>
<contributor>Maladies infectieuses et vecteurs : écologie, génétique, évolution et contrôle (MIVEGEC) ; Université de Montpellier (UM) - Centre National de la Recherche Scientifique (CNRS) - Institut de Recherche pour le Développement (IRD [France-Sud])</contributor>
<contributor>Royal Veterinary College [London] ; University of London [London]</contributor>
<contributor>Harvard Medical School [Boston] (HMS)</contributor>
<contributor>Brigham and Women's Hospital [Boston]</contributor>
<contributor>Rothamsted Research</contributor>
<contributor>Unité de modélisation mathématique et informatique des systèmes complexes [Bondy] (UMMISCO) ; Université Pierre et Marie Curie - Paris 6 (UPMC) - Institut de la francophonie pour l'informatique - Université Cheikh Anta Diop (UCAD) - Université Gaston Bergé (Saint-Louis, Sénégal) - Universtié Yaoundé 1 (Cameroun) - University Cadi Ayyad (UCA)</contributor>
<contributor>Epidemiologie des Parasitoses Tropicales (EPaT Team) ; Université des Antilles et de la Guyane (UAG) - Institut National de la Santé et de la Recherche Médicale (INSERM)</contributor>
<contributor>Service de Dermatologie [Cayenne, Guyanne Française] ; Centre Hospitalier Andre Rosemon</contributor>
<contributor>International Research Programme Future Earth</contributor>
<contributor>Biologie des Organismes et Ecosystèmes Aquatiques (BOREA) ; Muséum National d'Histoire Naturelle (MNHN) - Université Pierre et Marie Curie - Paris 6 (UPMC) - Centre National de la Recherche Scientifique (CNRS)</contributor>
<description>International audience</description>
<source>ISSN: 2222-1751</source>
<source>Emerging microbes & infections</source>
<identifier>hal-01528488</identifier>
<identifier>http://hal.upmc.fr/hal-01528488</identifier>
<identifier>http://hal.upmc.fr/hal-01528488/document</identifier>
<identifier>http://hal.upmc.fr/hal-01528488/file/emi20177a.pdf</identifier>
<source>http://hal.upmc.fr/hal-01528488</source>
<source>Emerging microbes & infections, 2017, 6, pp.e22. 〈10.1038/emi.2017.7〉</source>
<identifier>DOI : 10.1038/emi.2017.7</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1038/emi.2017.7</relation>
<language>en</language>
<subject>[SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases</subject>
<subject>[SDV.MHEP.ME] Life Sciences [q-bio]/Human health and pathology/Emerging diseases</subject>
<subject>[SDV.EE.SANT] Life Sciences [q-bio]/Ecology, environment/Health</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>Many emerging infectious diseases are caused by generalist pathogens that infect and transmit via multiple host species with multiple dissemination routes, thus confounding the understanding of pathogen transmission pathways from wildlife reservoirs to humans. The emergence of these pathogens in human populations has frequently been associated with global changes, such as socio-economic, climate or biodiversity modifications, by allowing generalist pathogens to invade and persist in new ecological niches, infect new host species, and thus change the nature of transmission pathways. Using the case of Buruli ulcer disease, we review how land-use changes, climatic patterns and biodiversity alterations contribute to disease emergence in many parts of the world. Here we clearly show that Mycobacterium ulcerans is an environmental pathogen characterized by multi-host transmission dynamics and that its infectious pathways to humans rely on the local effects of global environmental changes. We show that the interplay between habitat changes (for example, deforestation and agricultural land-use changes) and climatic patterns (for example, rainfall events), applied in a local context, can lead to abiotic environmental changes and functional changes in local biodiversity that favor the pathogen’s prevalence in the environment and may explain disease emergence.</description>
<rights>http://creativecommons.org/licenses/by/</rights>
<date>2017</date>
</dc>
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