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<datestamp>2017-12-21</datestamp>
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<title lang=en>GSTM1 and GSTT1 polymorphisms and the risk of prostate cancer in a Caribbean population of African descent.</title>
<creator>Mallick, Stéphane</creator>
<creator>Romana, Marc</creator>
<creator>Blanchet, Pascal</creator>
<creator>Multigner, Luc</creator>
<contributor>Service d'urologie ; Université des Antilles et de la Guyane (UAG) - CHU Pointe-à-Pitre</contributor>
<contributor>Université des Antilles et de la Guyane (UAG)</contributor>
<contributor>Groupe d'Etude de la Reproduction Chez l'Homme et les Mammiferes (GERHM) ; Université de Rennes 1 (UR1) - IFR140 - Institut National de la Santé et de la Recherche Médicale (INSERM)</contributor>
<contributor>the French Ministry of Health (PHRC); the Association pour la Recherche sur les Tumeurs de la Prostate; the Association pour la Recherche sur le Cancer</contributor>
<description>International audience</description>
<source>ISSN: 0090-4295</source>
<source>Urology</source>
<publisher>Elsevier</publisher>
<identifier>hal-00688449</identifier>
<identifier>https://hal.archives-ouvertes.fr/hal-00688449</identifier>
<source>https://hal.archives-ouvertes.fr/hal-00688449</source>
<source>Urology, Elsevier, 2007, 69 (6), pp.1165-9. 〈10.1016/j.urology.2007.02.039〉</source>
<identifier>DOI : 10.1016/j.urology.2007.02.039</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1016/j.urology.2007.02.039</relation>
<identifier>PUBMED : 17572208</identifier>
<relation>info:eu-repo/semantics/altIdentifier/pmid/17572208</relation>
<language>en</language>
<subject>[SDV.CAN] Life Sciences [q-bio]/Cancer</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>OBJECTIVES: To investigate whether the glutathione S-transferase polymorphisms GSTM1 and/or GSTT1 contribute to prostate cancer risk in a Caribbean population of African descent in Guadeloupe. METHODS: We performed a hospital-based case-control study with 134 prostate cancer patients and 134 cancer-free, age-matched control subjects. Epidemiologic data were collected using a standard questionnaire. Logistic regression was used to estimate odds ratios (ORs) and compute confidence intervals (CIs). Genotypes were determined by multiplex polymerase chain reaction. RESULTS: The frequency of the GSTM1-positive genotype was 81% in patients and 73% in control subjects, with an adjusted OR of 1.4 (95% CI 0.7 to 2.5). The frequency of the GSTT1-positive genotype was 78% in patients and 63% in control subjects, with an adjusted OR of 2.6 (95% CI 1.4 to 4.9). CONCLUSIONS: A functional GSTT1 polymorphism may be associated with prostate cancer susceptibility in a Caribbean population of African descent.</description>
<date>2007-06</date>
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