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<title lang=en>Immunomodulatory properties of HLA-G in infectious diseases</title>
<creator>Amiot, Laurence</creator>
<creator>Vu, Nicolas</creator>
<creator>Samson, Michel</creator>
<contributor>CHU Pontchaillou [Rennes]</contributor>
<contributor>Institut de recherche, santé, environnement et travail [Rennes] (Irset) ; Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )</contributor>
<contributor>This work was supported by grants from Inserm (Institut national de la santé et de la recherche médicale), University of Rennes 1, ANRS 2010, Ligue Nationale Contre le Cancer (Comité d’Ille et Vilaine) 2009, IFR 140 2010, and BioSit 2012. The authors thank Dr. Butterfield for generously providing the HMC1.1 human mast cell line, the Biological Resource Center (BRC) of Rennes University Hospital, and the H2P2 platform of BioSit.</contributor>
<description>International audience</description>
<source>ISSN: 2314-8861</source>
<source>EISSN: 2314-7156</source>
<source>Journal of Immunology Research</source>
<publisher>Hindawi Publishing Corporation</publisher>
<identifier>hal-01063925</identifier>
<identifier>https://hal.archives-ouvertes.fr/hal-01063925</identifier>
<identifier>https://hal.archives-ouvertes.fr/hal-01063925/document</identifier>
<identifier>https://hal.archives-ouvertes.fr/hal-01063925/file/Immunomodulatory%20Properties%20of%20HLA-G.pdf</identifier>
<source>https://hal.archives-ouvertes.fr/hal-01063925</source>
<source>Journal of Immunology Research, Hindawi Publishing Corporation, 2014, 2014, pp.298569. 〈10.1155/2014/298569〉</source>
<identifier>DOI : 10.1155/2014/298569</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1155/2014/298569</relation>
<identifier>PUBMED : 24839609</identifier>
<relation>info:eu-repo/semantics/altIdentifier/pmid/24839609</relation>
<language>en</language>
<subject>[SDV] Life Sciences [q-bio]</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>HLA-G is a nonclassical major histocompatibility complex molecule first described at the maternal-fetal interface, on extravillous cytotrophoblasts. Its expression is restricted to some tissues in normal conditions but increases strongly in pathological conditions. The expression of this molecule has been studied in detail in cancers and is now also beginning to be described in infectious diseases. The relevance of studies on HLA-G expression lies in the well known inhibitory effect of this molecule on all cell types involved in innate and adaptive immunity, favoring escape from immune control. In this review, we summarize the features of HLA-G expression by type of infections (i.e, bacterial, viral, or parasitic) detailing the state of knowledge for each pathogenic agent. The polymorphism, the interference of viral proteins with HLA-G intracellular trafficking, and various cytokines have been described to modulate HLA-G expression during infections. We also discuss the cellular source of HLA-G, according to the type of infection and the potential role of HLA-G. New therapeutic approaches based on synthetic HLA-G-derived proteins or antibodies are emerging in mouse models of cancer or transplantation, and these new therapeutic tools may eventually prove useful for the treatment of infectious diseases.</description>
<date>2014</date>
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