untitled
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<identifier>oai:HAL:hal-00387082v1</identifier>
<datestamp>2017-12-21</datestamp>
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<setSpec>subject:sdv</setSpec>
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<metadata><dc>
<publisher>HAL CCSD</publisher>
<title lang=en>Infectious complications in sickle cell disease and HLA polymorphism</title>
<creator>Joannes, Marie-Odile</creator>
<creator>Loko, Gylna</creator>
<creator>Deloumeaux, Jacqueline</creator>
<creator>Marianne-Pepin, Therese</creator>
<creator>Chout, Roger</creator>
<contributor>Epidémiologie Clinique et Médecine EA 4097 (ECM) ; UFR des sciences médicales de l'UAG</contributor>
<contributor>Laboratoire Dynamique des Protéines et Modélisation (LDPM) ; Université des Antilles et de la Guyane (UAG)</contributor>
<contributor>Contrat de bourse doctorale de la Région Martinique avec la collaboration du FSE</contributor>
<identifier>hal-00387082</identifier>
<identifier>https://hal.archives-ouvertes.fr/hal-00387082</identifier>
<identifier>https://hal.archives-ouvertes.fr/hal-00387082/document</identifier>
<identifier>https://hal.archives-ouvertes.fr/hal-00387082/file/MO_JOANNES_et_al_HLA_and_SCD.pdf</identifier>
<source>https://hal.archives-ouvertes.fr/hal-00387082</source>
<source>2009</source>
<language>en</language>
<subject lang=en>sickle cell</subject>
<subject lang=en>infection</subject>
<subject lang=en>polymorphism</subject>
<subject lang=en>genetic association</subject>
<subject lang=en>HLA class II alleles</subject>
<subject>[SDV.BBM] Life Sciences [q-bio]/Biochemistry, Molecular Biology</subject>
<subject>[SDV.IMM] Life Sciences [q-bio]/Immunology</subject>
<type>info:eu-repo/semantics/preprint</type>
<type>Preprints, Working Papers, ...</type>
<description lang=en>ABSTRACT Infectious complications are a leading cause of morbidity and mortality in patients with sickle cell disease. The exact reasons of the propensity of sickle cell patients to infection are not clear and are matter of debate. Besides, there is a striking variability of the clinical course of the disease between patients. This drew many scientists' attention. Genetic factors have been investigated as potential factor risks for infection in sickle cell patients, for example: HLA system; genes encoding Fc Human Immunoglobulin G receptor IIA, mannose-binding protein, and myeloperoxidase. Associations have been found, but all scientists agree that investigations have to be furthered. We investigated an association between HLA DRB1 and DQB1 polymorphism and infectious complications in sickle cell patients. Genotype frequencies were different between cases and controls for DRB1 locus. Indeed, HLA-DRB1*11 frequency was significantly higher in patients without infections than in patients with infections (χ² = 5.02; p = 0.025).</description>
<date>2009-03-06</date>
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