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<datestamp>2017-12-21</datestamp>
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<publisher>HAL CCSD</publisher>
<title lang=en>Indoleamine 2,3-dioxygenase activity as a potential biomarker of immune suppression during visceral leishmaniasis.</title>
<creator>Gangneux, Jean-Pierre</creator>
<creator>Poinsignon, Yves</creator>
<creator>Donaghy, Ludovic</creator>
<creator>Amiot, Laurence</creator>
<creator>Tarte, Karin</creator>
<creator>Mary, Charles</creator>
<creator>Robert-Gangneux, Florence</creator>
<contributor>Institut de recherche, santé, environnement et travail [Rennes] (Irset) ; Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )</contributor>
<contributor>Service de médecine interne ; CH Bretagne Sud</contributor>
<contributor>Service de Parasitologie-Mycologie [Rennes] ; Université de Rennes 1 (UR1) - Hôpital Pontchaillou - CHU Pontchaillou [Rennes]</contributor>
<contributor>Service d'Hématologie, Immunologie et de Thérapie Cellulaire (HITC) ; Université de Rennes 1 (UR1) - Hôpital Pontchaillou - CHU Pontchaillou [Rennes]</contributor>
<contributor>Microenvironnement et cancer (MiCa) ; Université de Rennes 1 (UR1) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )</contributor>
<contributor>Laboratoire de parasitologie-mycologie ; Assistance Publique - Hôpitaux de Marseille (APHM) - Hôpital de la Timone [CHU - APHM] (TIMONE)</contributor>
<description>International audience</description>
<source>Innate Immunity</source>
<identifier>inserm-00818884</identifier>
<identifier>http://www.hal.inserm.fr/inserm-00818884</identifier>
<source>http://www.hal.inserm.fr/inserm-00818884</source>
<source>Innate Immunity, 2013, 19 (6), pp.564-568. 〈10.1177/1753425912473170〉</source>
<identifier>DOI : 10.1177/1753425912473170</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1177/1753425912473170</relation>
<identifier>PUBMED : 23413147</identifier>
<relation>info:eu-repo/semantics/altIdentifier/pmid/23413147</relation>
<language>en</language>
<subject lang=it>Indoleamine 2</subject>
<subject lang=it>3-dioxygenase</subject>
<subject lang=it>immune reconstitution syndrome</subject>
<subject lang=it>visceral leishmaniasis</subject>
<subject lang=it>Leishmania</subject>
<subject lang=it>HLA-G</subject>
<subject lang=it>immune response</subject>
<subject>[SDV.IMM] Life Sciences [q-bio]/Immunology</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>Leishmania parasites induce an immunomodulation by subverting the host immune response towards a CD4(+) Th2 lymphocytic cell response that favors parasite persistence. Here, we report that after successful treatment of visceral leishmaniasis due to Leishmania infantum, an immune reconstitution syndrome revealing hip septic arthritis was associated with a switch from Th2 towards a Th1 cytokine profile, and a decrease in the level of immunomodulating factors, such as soluble HLA-G and indoleamine 2,3-dioxygenase (IDO) activity. We then measured IDO activity in a cohort of 39 patients and uninfected control subjects. Results showed significantly enhanced IDO activity in patients with visceral Leishmania infection, compared with uninfected control subjects (P < 0.001), but also compared with treated patients (P < 0.05). A decrease in IDO activity could constitute a relevant biomarker for the restoration of the immune response during visceral leishmaniasis.</description>
<date>2013-02-14</date>
</dc>
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