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<datestamp>2017-12-21</datestamp>
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<publisher>HAL CCSD</publisher>
<title lang=en>In Vitro Sensitivity of Cutaneous Leishmania Promastigote Isolates Circulating in French Guiana to a Set of Drugs.</title>
<creator>Ginouvès, Marine</creator>
<creator>Simon, Stéphane</creator>
<creator>Nacher, Mathieu</creator>
<creator>Demar, Magalie</creator>
<creator>Carme, Bernard</creator>
<creator>Couppié, Pierre</creator>
<creator>Prévot, Ghislaine</creator>
<contributor>Epidemiologie des Parasitoses Tropicales (EPaT Team) ; Université des Antilles et de la Guyane (UAG) - Institut National de la Santé et de la Recherche Médicale (INSERM)</contributor>
<contributor>Centre National de Référence Leishmania [Cayenne, Guyanne Française] (Laboratoire Associé) ; Laboratoire hospitalo-universitaire de Parasitologie et Mycologie Medicale ; Centre Hospitalier Andre Rosemon - Centre Hospitalier Andre Rosemon</contributor>
<contributor>Centre d'Investigation Clinique Antilles-Guyane (CIC - Antilles Guyane) ; Université des Antilles et de la Guyane (UAG) - Institut National de la Santé et de la Recherche Médicale (INSERM) - CHU de Pointe-à-Pitre - Centre Hospitalier de Cayenne Andrée Rosemon - CHU de Fort de France</contributor>
<contributor>Service des maladies infectieuses et tropicales [CHU Pitié-Salpêtrière] ; Assistance publique - Hôpitaux de Paris (AP-HP) - CHU Pitié-Salpêtrière [APHP]</contributor>
<contributor>Institut Guyanais de Dermatologie Tropicale, E.A. 2188 ; Centre Hospitalier Andrée Rosemon</contributor>
<contributor>This work was supported by the University of French Guiana and the Ministère Français de l’Enseignement Supérieur et de la Recherche Scientifique, the Conseil Régional de la Guyane and the European Union (FEDER-Presage N° 31454), and the “Investissement d’Avenir” grant managed by Agence Nationale de la Recherche (CEBA, ref. ANR-10-LABX-25-01).</contributor>
<description>International audience</description>
<source>ISSN: 0002-9637</source>
<source>American Journal of Tropical Medicine and Hygiene</source>
<publisher>American Society of Tropical Medicine and Hygiene</publisher>
<identifier>inserm-01481512</identifier>
<identifier>http://www.hal.inserm.fr/inserm-01481512</identifier>
<identifier>http://www.hal.inserm.fr/inserm-01481512/document</identifier>
<identifier>http://www.hal.inserm.fr/inserm-01481512/file/2017%2C%20Ginouves%20-%20In%20vitro%20sensitivity%20of%20cutaneous%20leishmania.pdf</identifier>
<source>http://www.hal.inserm.fr/inserm-01481512</source>
<source>American Journal of Tropical Medicine and Hygiene, American Society of Tropical Medicine and Hygiene, 2017, [Epub ahead of print]. 〈10.4269/ajtmh.16-0373〉</source>
<identifier>DOI : 10.4269/ajtmh.16-0373</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.4269/ajtmh.16-0373</relation>
<identifier>PUBMED : 28167598</identifier>
<relation>info:eu-repo/semantics/altIdentifier/pmid/28167598</relation>
<language>en</language>
<subject>[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>Anti-leishmaniasis drug resistance is a common problem worldwide. The aim of this study was to inventory the general in vitro level of sensitivity of Leishmania isolates circulating in French Guiana and to highlight potential in vitro pentamidine-resistant isolates. This sensitivity study was conducted on 36 patient-promastigote isolates for seven drugs (amphotericin B, azithromycin, fluconazole, meglumine antimoniate, miltefosine, paromomycin, and pentamidine) using the Cell Counting Kit-8 viability test. The IC50 values obtained were heterogeneous. One isolate exhibited high IC50 values for almost all drugs tested. Pentamidine, which is the first-line treatment in French Guiana, showed efficacy at very low doses (mean of 0.0038 μg/mL). The concordance of the in vitro pentamidine results with the patients' clinical outcomes was 94% (K = 0.82).</description>
<date>2017-02-06</date>
<contributor>ANR-10-LABX-25-01/10-LABX-0025, CEBA, CEnter of the study of Biodiversity in Amazonia(2010)</contributor>
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