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<datestamp>2017-12-21</datestamp>
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<publisher>HAL CCSD</publisher>
<title lang=en>Incidence and predictive factors of transaminase elevation in patients consulting for dengue fever in Cayenne Hospital, French Guiana</title>
<creator>Djossou, Félix</creator>
<creator>Vesin, Guillaume</creator>
<creator>Walter, Gaelle</creator>
<creator>Epelboin, Loïc</creator>
<creator>Mosnier, Emilie</creator>
<creator>Bidaud, Bastien</creator>
<creator>Abboud, Philippe</creator>
<creator>Okandze, Antoine</creator>
<creator>Mattheus, Severine</creator>
<creator>Elenga, Narcisse</creator>
<creator>Demar, Magalie</creator>
<creator>Malvy, Denis</creator>
<creator>Nacher, Mathieu</creator>
<contributor>Unité des Maladies Infectieuses et Tropicales [Cayenne, Guyanne Française] ; Centre Hospitalier de Cayenne Andrée Rosemon</contributor>
<contributor> Écosystèmes amazoniens et pathologie tropicale [Cayenne, Guyanne Française] ; Université de Guyane (UG)</contributor>
<contributor>Département des Centres Délocalisés de Prévention et de Soins [Cayenne, Guyanne Française] ; Centre Hospitalier de Cayenne Andrée Rosemon</contributor>
<contributor>Laboratoire Polyvalent [Cayenne, Guyanne Française] ; Centre Hospitalier de Cayenne</contributor>
<contributor>Laboratoire de virologie [Cayenne, Guyanne Française] ; Institut Pasteur de la Guyane</contributor>
<contributor>Service de Pédiatrie [Cayenne, Guyanne Française] ; Centre Hospitalier de Cayenne Andrée Rosemon</contributor>
<contributor>Laboratoire de Parasitologie Mycologie [Cayenne, Guyanne Française] ; Centre Hospitalier de Cayenne "Andrée ROSEMON"</contributor>
<contributor>Unités maladies tropicales et du voyageur [Bordeaux] ; CHU Bordeaux [Bordeaux] - Hôpital Saint-André - Bordeaux</contributor>
<contributor>Centre d'Investigation Clinique Antilles-Guyane (CIC - Antilles Guyane) ; Université des Antilles et de la Guyane (UAG) - Institut National de la Santé et de la Recherche Médicale (INSERM) - CHU de Pointe-à-Pitre - Centre Hospitalier de Cayenne Andrée Rosemon - CHU de Fort de France</contributor>
<description>International audience</description>
<source>ISSN: 0035-9203</source>
<source>Transactions of The Royal Society of Tropical Medicine and Hygiene</source>
<publisher>Oxford University Press (OUP)</publisher>
<identifier>inserm-01475594</identifier>
<identifier>http://www.hal.inserm.fr/inserm-01475594</identifier>
<identifier>http://www.hal.inserm.fr/inserm-01475594/document</identifier>
<identifier>http://www.hal.inserm.fr/inserm-01475594/file/2016%2C%20Djossou%20-%20Incidence%20and%20predictive%20factors%20of%20transaminase.pdf</identifier>
<source>http://www.hal.inserm.fr/inserm-01475594</source>
<source>Transactions of The Royal Society of Tropical Medicine and Hygiene, Oxford University Press (OUP), 2016, 110 (2), pp.134 - 140. 〈10.1093/trstmh/trv117〉</source>
<identifier>DOI : 10.1093/trstmh/trv117</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1093/trstmh/trv117</relation>
<identifier>PUBMED : 26822606</identifier>
<relation>info:eu-repo/semantics/altIdentifier/pmid/26822606</relation>
<language>en</language>
<subject lang=en>Paracetamol</subject>
<subject lang=en>Predictors</subject>
<subject lang=en>Transaminase elevation</subject>
<subject lang=en>Dengue</subject>
<subject>[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>Background: The objective of the study was to determine the incidence of transaminase elevation during dengue, and its predictive factors. Methods: In 2013, a longitudinal study was performed using data from all cases of dengue seen in Cayenne Hospital. Cox proportional modeling was used. Signs of major transaminase elevation were defined as an increase in aspartate amino transferase (AST) or alanine amino transferase (ALT) concentration over 10 times the normal value (10N). Results: There were 1574 patients and 13 249 person-days of follow-up. The incidence rate for signs of trans-aminase elevation (10N) was 0.55 per 100 person-days. Six patients had major transaminase elevation with AST.1000 units (0.43 per 1000 patient-days), and 73 patients (4.6%) developed transaminase elevation with AST .10N. The variables independently associated with major transaminase elevation were hyponatremia, low platelets, dehydration, hematocrit increase, food intolerance, positive nonstructural protein 1 (NS1), age over 15 years and the notion of paracetamol intake. Conclusions: Although very frequent, the incidence of major transaminase elevation was lower than reported elsewhere perhaps because of good access to care, or of the particular serotype causing this epidemic. The patients with transaminase elevation tended to be older, more severe and taking paracetamol.</description>
<date>2016-02</date>
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