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<datestamp>2017-12-21</datestamp>
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<publisher>HAL CCSD</publisher>
<title lang=en>Incidence and Predictive Factors of Central Nervous System Dysfunction in Patients Consulting for Dengue Fever in Cayenne Hospital, French Guiana.</title>
<creator>Djossou, Félix</creator>
<creator>Vesin, Guillaume</creator>
<creator>Bidaud, Bastien</creator>
<creator>Mosnier, Emilie</creator>
<creator>Simonnet, Christine</creator>
<creator>Matheus, Séverine</creator>
<creator>Prince, Christelle</creator>
<creator>Balcaen, John</creator>
<creator>Donutil, Gerd</creator>
<creator>Egmann, Gérald</creator>
<creator>Okandze, Antoine</creator>
<creator>Malvy, Denis</creator>
<creator>Nacher, Mathieu</creator>
<contributor>Unité des Maladies Infectieuses et Tropicales ; Centre Hospitalier de Cayenne Andrée Rosemon</contributor>
<contributor> Écosystèmes amazoniens et pathologie tropicale ; Université de Guyane (UG)</contributor>
<contributor>Département des Centres Délocalisés de Prévention et de Soins ; Centre Hospitalier de Cayenne Andrée Rosemon</contributor>
<contributor>Centre Hospitalier de Cayenne Andrée Rosemon</contributor>
<contributor>Institut Pasteur de la Guyane</contributor>
<contributor>Service des Maladies Infectieuses et Tropicales A [Bordeaux] ; CHU Bordeaux [Bordeaux] - Groupe hospitalier Pellegrin</contributor>
<contributor>Epidemiologie des Parasitoses Tropicales (EPaT Team) ; Université des Antilles et de la Guyane (UAG) - Institut National de la Santé et de la Recherche Médicale (INSERM)</contributor>
<contributor>Centre d'Investigation Clinique Antilles-Guyane (CIC - Antilles Guyane) ; Université des Antilles et de la Guyane (UAG) - Institut National de la Santé et de la Recherche Médicale (INSERM) - CHU de Pointe-à-Pitre - Centre Hospitalier de Cayenne Andrée Rosemon - CHU de Fort de France</contributor>
<description>International audience</description>
<source>ISSN: 1932-6203</source>
<source>PLoS ONE</source>
<publisher>Public Library of Science</publisher>
<identifier>inserm-01421218</identifier>
<identifier>http://www.hal.inserm.fr/inserm-01421218</identifier>
<identifier>http://www.hal.inserm.fr/inserm-01421218/document</identifier>
<identifier>http://www.hal.inserm.fr/inserm-01421218/file/2016%2C%20Djossou%20-%20Incidence%20and%20Predictive%20Factors%20of%20Central%20Nervous%20System%20Dysfunction%20in%20Patients%20Consulting.pdf</identifier>
<source>http://www.hal.inserm.fr/inserm-01421218</source>
<source>PLoS ONE, Public Library of Science, 2016, 11 (3), pp.e0150828. 〈10.1371/journal.pone.0150828.t003〉</source>
<identifier>DOI : 10.1371/journal.pone.0150828.t003</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pone.0150828.t003</relation>
<identifier>PUBMED : 26981859</identifier>
<relation>info:eu-repo/semantics/altIdentifier/pmid/26981859</relation>
<language>en</language>
<subject>[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=0>INTRODUCTION:The frequency, the clinical characteristics, and the prognosis of dengue is highly variable. Dengue fever is associated with a range of neurological manifestations. The objective of the present study was to determine the incidence of neurological signs and their predictive factors using data from cases of dengue seen and followed in Cayenne Hospital during the Dengue 2 epidemic in 2013.METHODS:In 2013, a longitudinal study using data from all cases of dengue seen in Cayenne hospital was collected. Medical records used a standardized form to collect demographic information, clinical signs and biological results and the date at which they were present. The analysis used Cox proportional modeling to obtain adjusted Hazard ratios.RESULTS:A total of 1574 patients were included 221 of whom developed central nervous system signs. These signs were spontaneously resolutive. There were 9298person days of follow-up and the overall incidence rate for central nervous system signs was 2.37 per 100 person-days. The variables independently associated with central nervous system anomalies were headache, Adjusted Hazard ratio (AHR) = 1.9(95%CI = 1.4-2.6), bleeding AHR = 2 ((95%CI = 1.3-3.1), P = 0.001, abdominal pain AHR = 1.9 ((95%CI = 1.4-2.6), P<0.001, aches AHR = 2.1 ((95%CI = 1.5-2.9), P<0.001, and fatigue AHR = 1.5 ((95%CI = 1.3-1.7), P<0.001.DISCUSSION:Overall, the present study suggests that neurological signs of dengue are not exceptional even in patients without the most severe features of dengue. These manifestations were spontaneously resolutive. Here it was not possible to distinguish between encephalitis or encephalopathy. Further studies would require more in depth exploration of the patients.</description>
<date>2016-03-16</date>
<contributor>ANR : CEBA, ANR-10-LABX-0025</contributor>
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