untitled
<OAI-PMH schemaLocation=http://www.openarchives.org/OAI/2.0/ http://www.openarchives.org/OAI/2.0/OAI-PMH.xsd>
<responseDate>2018-01-17T12:05:24Z</responseDate>
<request identifier=oai:HAL:hal-00682104v1 verb=GetRecord metadataPrefix=oai_dc>http://api.archives-ouvertes.fr/oai/hal/</request>
<GetRecord>
<record>
<header>
<identifier>oai:HAL:hal-00682104v1</identifier>
<datestamp>2017-12-21</datestamp>
<setSpec>type:ART</setSpec>
<setSpec>subject:sdv</setSpec>
<setSpec>collection:BIOSIT</setSpec>
<setSpec>collection:IRSET-3</setSpec>
<setSpec>collection:IFR140</setSpec>
<setSpec>collection:IRSET-2</setSpec>
<setSpec>collection:USPC</setSpec>
<setSpec>collection:STATS-UR1</setSpec>
<setSpec>collection:EHESP</setSpec>
<setSpec>collection:UR1-HAL</setSpec>
<setSpec>collection:UR1-SDV</setSpec>
<setSpec>collection:UR1-UFR-SVE</setSpec>
<setSpec>collection:IRSET</setSpec>
<setSpec>collection:UNIV-RENNES1</setSpec>
<setSpec>collection:IRSET-SMS</setSpec>
<setSpec>collection:UNIV-AG</setSpec>
<setSpec>collection:UNIV-ANGERS</setSpec>
</header>
<metadata><dc>
<publisher>HAL CCSD</publisher>
<title lang=en>Identification of the couple GSK3α/c-Myc as a new regulator of hexokinase II in benzo[a]pyrene-induced apoptosis.</title>
<creator>Dendelé, Béatrice</creator>
<creator>Tekpli, Xavier</creator>
<creator>Sergent, Odile</creator>
<creator>Dimanche-Boitrel, Marie-Thérèse</creator>
<creator>Holme, Jørn, </creator>
<creator>Huc, Laurence</creator>
<creator>Lagadic-Gossmann, Dominique</creator>
<contributor>Institut de recherche, santé, environnement et travail [Rennes] (Irset) ; Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )</contributor>
<contributor>Stress, membrane, signalisation ; Institut de recherche, santé, environnement et travail [Rennes] (Irset) ; Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ) - Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )</contributor>
<contributor>Division of Environmental Medicine ; Norwegian Institute of Public Health</contributor>
<contributor>Ligue Nationale contre le Cancer</contributor>
<description>International audience</description>
<source>ISSN: 0887-2333</source>
<source>Toxicology in Vitro</source>
<publisher>Elsevier</publisher>
<identifier>hal-00682104</identifier>
<identifier>https://hal.archives-ouvertes.fr/hal-00682104</identifier>
<identifier>https://hal.archives-ouvertes.fr/hal-00682104/document</identifier>
<identifier>https://hal.archives-ouvertes.fr/hal-00682104/file/1-s2.0-S0887233311003018-main%20Dendel%C3%A9_%7B75929874-2DF9-47C3-92F6-92AF398668E5%7D.pdf</identifier>
<source>https://hal.archives-ouvertes.fr/hal-00682104</source>
<source>Toxicology in Vitro, Elsevier, 2012, 26 (1), pp.94-101. 〈10.1016/j.tiv.2011.11.001〉</source>
<identifier>DOI : 10.1016/j.tiv.2011.11.001</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1016/j.tiv.2011.11.001</relation>
<identifier>PUBMED : 22100782</identifier>
<relation>info:eu-repo/semantics/altIdentifier/pmid/22100782</relation>
<language>en</language>
<subject lang=en>GSK3</subject>
<subject lang=en>Hexokinase II</subject>
<subject lang=en>c-Myc</subject>
<subject lang=en>Apoptosis</subject>
<subject lang=en>Mitochondria</subject>
<subject lang=en>Benzo[a]pyrene</subject>
<subject lang=en>NHE1</subject>
<subject>[SDV.TOX] Life Sciences [q-bio]/Toxicology</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>The early apoptotic events induced by environmental pollutants with carcinogenic properties are poorly understood. Here, we focus on the early cytotoxic effects of benzo[a]pyrene (B[a]P). In F258 rat hepatic epithelial cells, B[a]P induces intrinsic apoptosis via a mitochondrial dysfunction characterized by the release of hexokinase II (HKII) from the mitochondria. Cancer cells often have an anomalous cell energy metabolism; since HKII dysfunction regulates B[a]P-induced apoptosis in F258 cells, but may also alter cell energy metabolism, HKII release from the mitochondria may represent an important B[a]P-related carcinogenic issue. Thus in the present study, we aimed at deciphering the mechanisms underlying HKII dysfunction upon B[a]P exposure. We show that while glycogen synthase kinase 3 beta (GSK3β) regulated the expression of HKII at the transcriptional level, glycogen synthase kinase 3 alpha (GSK3α) was involved in B[a]P-induced apoptosis via a decrease in c-Myc expression. The reduced level of c-Myc caused the relocation of HKII from the mitochondria to the cytosol, thereby being involved in the formation of reactive oxygen species and apoptosis. In conclusion, we show that the couple GSK3α/c-Myc plays a key role in B[a]P-induced early apoptotic cell signaling via HKII dysfunction.</description>
<date>2012-02</date>
</dc>
</metadata>
</record>
</GetRecord>
</OAI-PMH>
