untitled
<OAI-PMH schemaLocation=http://www.openarchives.org/OAI/2.0/ http://www.openarchives.org/OAI/2.0/OAI-PMH.xsd>
<responseDate>2018-01-15T18:30:55Z</responseDate>
<request identifier=oai:HAL:hal-00996401v1 verb=GetRecord metadataPrefix=oai_dc>http://api.archives-ouvertes.fr/oai/hal/</request>
<GetRecord>
<record>
<header>
<identifier>oai:HAL:hal-00996401v1</identifier>
<datestamp>2018-01-15</datestamp>
<setSpec>type:ART</setSpec>
<setSpec>subject:chim</setSpec>
<setSpec>collection:UNIV-AG</setSpec>
<setSpec>collection:CNRS</setSpec>
<setSpec>collection:UNIV-ROUEN</setSpec>
<setSpec>collection:CIRAD</setSpec>
<setSpec>collection:AGROPARISTECH</setSpec>
<setSpec>collection:IFR140</setSpec>
<setSpec>collection:UNIV-RENNES1</setSpec>
<setSpec>collection:IGDR</setSpec>
<setSpec>collection:ECOFOG</setSpec>
<setSpec>collection:INRA</setSpec>
<setSpec>collection:BIOSIT</setSpec>
<setSpec>collection:COMUE-NORMANDIE</setSpec>
<setSpec>collection:INC-CNRS</setSpec>
<setSpec>collection:UR1-UFR-SVE</setSpec>
<setSpec>collection:UR1-HAL</setSpec>
<setSpec>collection:UR1-SDV</setSpec>
<setSpec>collection:INSA-ROUEN</setSpec>
</header>
<metadata><dc>
<publisher>HAL CCSD</publisher>
<title lang=en>Identification and characterization of a novel antimicrobial peptide from the venom of the ant Tetramorium bicarinatum.</title>
<creator>Rifflet, Aline</creator>
<creator>Gavalda, Sabine</creator>
<creator>Téné, Nathan</creator>
<creator>Orivel, Jérôme</creator>
<creator>Leprince, Jérôme</creator>
<creator>Guilhaudis, Laure</creator>
<creator>Génin, Eric</creator>
<creator>Vétillard, Angélique</creator>
<creator>Treilhou, Michel</creator>
<contributor>Ecologie des forêts de Guyane (ECOFOG) ; Centre de Coopération Internationale en Recherche Agronomique pour le Développement (CIRAD) - Institut National de la Recherche Agronomique (INRA) - Université des Antilles et de la Guyane (UAG) - AgroParisTech - Centre National de la Recherche Scientifique (CNRS)</contributor>
<contributor>Différenciation et communication neuronale et neuroendocrine (DC2N) ; Université de Rouen Normandie (URN) ; Normandie Université (NU) - Normandie Université (NU) - Institut National de la Santé et de la Recherche Médicale (INSERM)</contributor>
<contributor>Chimie Organique et Bioorganique : Reactivité et Analyse (COBRA) ; Centre National de la Recherche Scientifique (CNRS) - Institut de Chimie Organique Fine (IRCOF) ; Université de Rouen Normandie (URN) ; Normandie Université (NU) - Normandie Université (NU) - Institut national des sciences appliquées Rouen Normandie (INSA Rouen Normandie) ; Normandie Université (NU) - Centre National de la Recherche Scientifique (CNRS) - Université de Rouen Normandie (URN) ; Normandie Université (NU) - Normandie Université (NU) - Institut national des sciences appliquées Rouen Normandie (INSA Rouen Normandie) ; Normandie Université (NU) - Centre National de la Recherche Scientifique (CNRS)</contributor>
<contributor>Interactions cellulaires et moléculaires (ICM) ; Université de Rennes 1 (UR1) - IFR140 - Centre National de la Recherche Scientifique (CNRS)</contributor>
<description>International audience</description>
<source>ISSN: 0196-9781</source>
<source>Peptides</source>
<publisher>Elsevier</publisher>
<identifier>hal-00996401</identifier>
<identifier>https://hal.archives-ouvertes.fr/hal-00996401</identifier>
<source>https://hal.archives-ouvertes.fr/hal-00996401</source>
<source>Peptides, Elsevier, 2012, 38 (2), pp.363-70. 〈10.1016/j.peptides.2012.08.018〉</source>
<identifier>DOI : 10.1016/j.peptides.2012.08.018</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1016/j.peptides.2012.08.018</relation>
<identifier>PUBMED : 22960382</identifier>
<relation>info:eu-repo/semantics/altIdentifier/pmid/22960382</relation>
<language>en</language>
<subject>[CHIM.ORGA] Chemical Sciences/Organic chemistry</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>A novel antimicrobial peptide, named Bicarinalin, has been isolated from the venom of the ant Tetramorium bicarinatum. Its amino acid sequence has been determined by de novo sequencing using mass spectrometry and by Edman degradation. Bicarinalin contained 20 amino acid residues and was C-terminally amidated as the majority of antimicrobial peptides isolated to date from insect venoms. Interestingly, this peptide had a linear structure and exhibited no meaningful similarity with any known peptides. Antibacterial activities against Staphylococcus aureus and S. xylosus strains were evaluated using a synthetic replicate. Bicarinalin had a potent and broad antibacterial activity of the same magnitude as Melittin and other hymenopteran antimicrobial peptides such as Pilosulin or Defensin. Moreover, this antimicrobial peptide has a weak hemolytic activity compared to Melittin on erythrocytes, suggesting potential for development into an anti-infective agent for use against emerging antibiotic-resistant pathogens.</description>
<date>2012-12</date>
</dc>
</metadata>
</record>
</GetRecord>
</OAI-PMH>
