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<identifier>oai:HAL:hal-00875955v1</identifier>
<datestamp>2017-12-21</datestamp>
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<publisher>HAL CCSD</publisher>
<title lang=en>Influence of fetal glutathione S-transferase copy number variants on adverse reproductive outcomes.</title>
<creator>Bustamante, M.</creator>
<creator>Danileviciute, A.</creator>
<creator>Espinosa, A.</creator>
<creator>Gonzalez, J. R.</creator>
<creator>Subirana, I.</creator>
<creator>Cordier, Sylvaine</creator>
<creator>Chevrier, Cécile</creator>
<creator>Chatzi, L.</creator>
<creator>Grazuleviciene, R.</creator>
<creator>Sunyer, J.</creator>
<creator>Ibarluzea, J.</creator>
<creator>Ballester, F.</creator>
<creator>Villanueva, C. M.</creator>
<creator>Nieuwenhuijsen, M.</creator>
<creator>Estivill, X.</creator>
<creator>Kogevinas, M.</creator>
<contributor>Center for Research in Environmental Epidemiology (CREAL) ; Universitat Pompeu Fabra [Barcelona] - Catalunya ministerio de salud</contributor>
<contributor>Vytautas Magnus University ; Vytautas Magnus University</contributor>
<contributor>IMIM-Hospital del Mar ; Generalitat de Catalunya</contributor>
<contributor>Institut de recherche, santé, environnement et travail [Rennes] (Irset) ; Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )</contributor>
<contributor>Center for Public Health Research (CSISP) ; University of Valencia</contributor>
<description>International audience</description>
<source>ISSN: 1470-0328</source>
<source>EISSN: 1471-0528</source>
<source>BJOG: An International Journal of Obstetrics and Gynaecology</source>
<publisher>Wiley</publisher>
<identifier>hal-00875955</identifier>
<identifier>https://hal.archives-ouvertes.fr/hal-00875955</identifier>
<source>https://hal.archives-ouvertes.fr/hal-00875955</source>
<source>BJOG: An International Journal of Obstetrics and Gynaecology, Wiley, 2012, 119 (9), pp.1141-6. 〈10.1111/j.1471-0528.2012.03400.x〉</source>
<identifier>DOI : 10.1111/j.1471-0528.2012.03400.x</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1111/j.1471-0528.2012.03400.x</relation>
<identifier>PUBMED : 22676722</identifier>
<relation>info:eu-repo/semantics/altIdentifier/pmid/22676722</relation>
<language>en</language>
<subject lang=en>Copy number variant</subject>
<subject lang=en>glutathione S-transferase</subject>
<subject lang=en>preterm</subject>
<subject lang=en>small for gestational age</subject>
<subject>[SDV.MHEP.GEO] Life Sciences [q-bio]/Human health and pathology/Gynecology and obstetrics</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>A nested case-control association study was designed to investigate the influence of maternal and fetal copy number variants (CNVs) on reproductive outcomes. Genotypes of ten CNVs encompassing GST and CYP genes were assessed. Significant associations were only found for child CNV genotypes. In particular, the child GSTM1 insertion allele was associated with prematurity protection (odds ratio, 95% CI: 0.67, 0.51-0.89; P < 0.01), whereas the child GSTT2B insertion allele was associated with an increased risk of being small for gestational age (odds ratio, 95% CI: 1.33, 1.07-1.67; P = 0.01). The study highlights the role of the fetal genome in prenatal development and also the need to analyse CNVs in a systematic manner.</description>
<date>2012-08</date>
</dc>
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