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<title lang=en>Incidence, medical and socio-behavioural predictors of psychiatric events in an 11-year follow-up of HIV-infected patients on antiretroviral therapy.</title>
<creator>Protopopescu, Camelia</creator>
<creator>Raffi, François</creator>
<creator>Brunet-François, Cécile</creator>
<creator>Salmon, Dominique</creator>
<creator>Verdon, Renaud</creator>
<creator>Reboud, Philippe</creator>
<creator>Carrieri, Maria Patrizia</creator>
<creator>Leport, Catherine</creator>
<creator>Spire, Bruno</creator>
<creator>Michel, Laurent</creator>
<creator>Michelet, Christian</creator>
<contributor>Aix Marseille Université (AMU)</contributor>
<contributor>Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale (SESSTIM) ; Institut de Recherche pour le Développement (IRD) - Aix Marseille Université (AMU) - ORS PACA - Institut National de la Santé et de la Recherche Médicale (INSERM)</contributor>
<contributor>Maladies infectieuses et tropicales</contributor>
<contributor>Service de médecine interne et centre de référence des maladies rares [CHU Cochin] ; CHU Cochin [AP-HP] - Assistance publique - Hôpitaux de Paris (AP-HP)</contributor>
<contributor>Service des maladies infectieuses et tropicales ; CHU Caen</contributor>
<contributor>Epidémiologie et Biostatistique [Bordeaux] ; Université Bordeaux Segalen - Bordeaux 2 - Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED) - Institut National de la Santé et de la Recherche Médicale (INSERM)</contributor>
<contributor>Modèles et méthodes de l'évaluation thérapeutique des maladies chroniques ; Université Paris Diderot - Paris 7 (UPD7) - Institut National de la Santé et de la Recherche Médicale (INSERM)</contributor>
<contributor>Troubles du comportement alimentaire de l'adolescent (UMR_S 669) ; Université Paris Descartes - Paris 5 (UPD5) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Université Paris-Sud - Paris 11 (UP11)</contributor>
<contributor>Institut de recherche, santé, environnement et travail [Rennes] (Irset) ; Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )</contributor>
<description>International audience</description>
<source>ISSN: 1359-6535</source>
<source>Antiviral Therapy</source>
<publisher>International Medical Press</publisher>
<identifier>hal-00875183</identifier>
<identifier>https://hal.archives-ouvertes.fr/hal-00875183</identifier>
<source>https://hal.archives-ouvertes.fr/hal-00875183</source>
<source>Antiviral Therapy, International Medical Press, 2012, 17 (6), pp.1079-83. 〈10.3851/IMP2102〉</source>
<identifier>DOI : 10.3851/IMP2102</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.3851/IMP2102</relation>
<identifier>PUBMED : 22544079</identifier>
<relation>info:eu-repo/semantics/altIdentifier/pmid/22544079</relation>
<language>en</language>
<subject lang=en>Immunopathology</subject>
<subject lang=en>Immune deficiency</subject>
<subject lang=en>Infection</subject>
<subject lang=en>Viral disease</subject>
<subject lang=en>Antiretroviral agent</subject>
<subject lang=en>Chemotherapy</subject>
<subject lang=en>Antiviral</subject>
<subject lang=en>Treatment</subject>
<subject lang=en>AIDS</subject>
<subject lang=en>Predictive factor</subject>
<subject lang=en>Epidemiology</subject>
<subject lang=en>Incidence</subject>
<subject>[SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>BACKGROUND: Psychiatric disorders are relatively common among HIV-infected patients. However, there are few studies about their potential risk factors. This analysis aimed to measure the incidence of severe psychiatric events (PE) among patients receiving combination antiretroviral therapy (cART) of the French APROCO-COPILOTE (ANRS CO8) cohort, and to identify the medical and socio-behavioural correlates of their first episode of depression, suicide or suicide attempt (D/S/SA). METHODS: APROCO-COPILOTE is a cohort of patients started on a protease inhibitor regimen between 1997 and 1999, with prospective medical standardized records and self-administered questionnaires collecting socio-demographic and socio-behavioural data. This analysis included all 11-year follow-up visits for 1,095 patients having completed baseline self-administered questionnaires. A proportional hazard Cox model was used to identify the correlates of a first D/S/SA event. RESULTS: The overall prevalence of severe PE remained low: 50 patients experienced 67 events (incidence rate [95% CI] =1.04 [0.82, 1.32] per 100 person-years). Depression (n=16), suicides (n=5) and suicide attempts (n=14) were the most frequently diagnosed PE (0.54 [0.39, 0.76] per 100 person-years) among 25 patients. Multivariate results showed that unemployment, unstable housing, detectable viral load and smoking more than 20 cigarettes/day were independently associated with D/S/SA. CONCLUSIONS: Although the incidence of severe PE remained relatively low among the patients of APROCO-COPILOTE cohort, this study's results underline a clinically important problem in HIV-infected patients receiving cART. Furthermore, our findings not only emphasize the importance of comprehensive care, especially for socially vulnerable patients, but may also help future studies designed to assess the effectiveness of interventions in reducing the risk of PE during cART.</description>
<contributor>APROCO-COPILOTE (ANRS CO8) Study Group</contributor>
<date>2012</date>
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