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<publisher>HAL CCSD</publisher>
<title lang=en>Is there a relationship between the hematocrit-to-viscosity ratio and microvascular oxygenation in brain and muscle?</title>
<creator>Waltz, Xavier</creator>
<creator>Hardy-Dessources, Marie-Dominique</creator>
<creator>Lemonne, Nathalie</creator>
<creator>Ele Mougenel, Danì</creator>
<creator>Lalanne-Mistrih, Marie-Laure</creator>
<creator>Lamarre, Yann</creator>
<creator>Tarer, Vanessa</creator>
<creator>Eres, Benoittressì</creator>
<creator>Etienne-Julan, Maryse</creator>
<creator>Hue, Olivier</creator>
<creator>Connes, Philippe</creator>
<contributor>Adaptations au Climat Tropical, Exercice et Santé (ACTES) ; Université des Antilles et de la Guyane (UAG)</contributor>
<contributor>Centre d'investigation clinique Antilles-Guyane ; Institut National de la Santé et de la Recherche Médicale (INSERM) - CH Cayenne</contributor>
<contributor>Laboratory of Excellence GR-Ex "The red cell: from genesis to death" ; PRES Sorbonne Paris Cité</contributor>
<contributor>Protéines de la membrane érythrocytaire et homologues non-érythroides ; Université des Antilles et de la Guyane (UAG) - Institut National de la Transfusion Sanguine [Paris] (INTS) - Université Paris Diderot - Paris 7 (UPD7) - Université de la Réunion (UR) - Institut National de la Santé et de la Recherche Médicale (INSERM)</contributor>
<contributor>CHU de Pointe-à-Pitre ; CHU de Pointe-à-Pitre</contributor>
<contributor>Centre de référence maladies rares pour la drépanocytose aux Antilles-Guyane ; Centre Hospitalier et Universitaire de Pointe-à-Pitre</contributor>
<description>International audience</description>
<source>ISSN: 1386-0291</source>
<source>Clinical Hemorheology and Microcirculation</source>
<publisher>IOS Press</publisher>
<identifier>hal-01163460</identifier>
<identifier>https://hal.univ-antilles.fr/hal-01163460</identifier>
<source>https://hal.univ-antilles.fr/hal-01163460</source>
<source>Clinical Hemorheology and Microcirculation, IOS Press, 2015, 59, pp.37-43. 〈10.3233/CH-131742〉</source>
<identifier>DOI : 10.3233/CH-131742</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.3233/CH-131742</relation>
<language>en</language>
<subject lang=en>hemorheology</subject>
<subject lang=en>sickle cell syndromes</subject>
<subject lang=en>Microvascular oxygenation</subject>
<subject>[SDV] Life Sciences [q-bio]</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>The hematocrit-to-viscosity ratio (HVR) has been widely used has an estimate of red blood cell (RBC) oxygen transport effectiveness into the microvasculature or as an oxygen delivery index. However, no study investigated the possibility of HVR to truly reflect RBC oxygen transport effectiveness or to be an oxygen delivery index. We measured blood viscosity at high shear rate (225 s −1), hematocrit, HVR, as well as the microvascular oxyhemoglobin saturation (TOI; tissue oxygen index) by spatial resolved near-infrared spectroscopy (NIRS) at cerebral and muscle levels in three population known to have various degrees of hemorheological abnormalities: healthy subjects (AA), patients with sickle cell SC disease (SC) characterized by moderate anemia and patients with sickle cell anemia (SS) marked by severe anemia. At both the cerebral and muscle level, HVR was positively correlated with TOI (r = 0.28; p = 0.03 and r = 0.38; p = 0.003, at the cerebral and muscle level, respectively). These findings suggest that HVR probably play a key role in blood flow and hemodynamic regulation in the microvasculature, hence modulating the amount of oxygen available for tissues. Nevertheless, the strengths of the associations are weak (R 2 < 0.50), suggesting that other determinants modulate microvascular blood flow and oxygenation, such as vascular geometry and vasomotor reserve.</description>
<date>2015</date>
</dc>
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