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<datestamp>2017-12-21</datestamp>
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<title lang=en>Ibuprofen results in alterations of human fetal testis development</title>
<creator>Ben Maamar, M.</creator>
<creator>Lesné, L.</creator>
<creator>Hennig, K.</creator>
<creator>Desdoits-Lethimonier, C.</creator>
<creator>Kilcoyne, K.R.</creator>
<creator>Coiffec, I.</creator>
<creator>Rolland, A.D.</creator>
<creator>Chevrier, C.</creator>
<creator>Kristensen, D.M.</creator>
<creator>Lavoue, V.</creator>
<creator>Antignac, J.-P.</creator>
<creator>Le Bizec, B.</creator>
<creator>Dejucq-Rainsford, N.</creator>
<creator>Mitchell, R.T.</creator>
<creator>Mazaud-Guittot, S.</creator>
<creator>Jégou, B.</creator>
<contributor>Institut de recherche, santé, environnement et travail [Rennes] (Irset) ; Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )</contributor>
<contributor>Unité sous contrat Laboratoire d'étude des résidus et contaminants dans les aliments ; Institut National de la Recherche Agronomique (INRA) - Ecole Nationale Vétérinaire de Nantes</contributor>
<contributor>Oniris, LABERCA ; Université Nantes Angers Le Mans</contributor>
<contributor>The Queen’s Medical Research Institute, MRC Centre for Reproductive Health ; University of Edinburgh</contributor>
<contributor>CHU Pontchaillou [Rennes]</contributor>
<contributor>Oncogenesis Stress Signaling (OSS) ; Université de Rennes 1 (UR1) - CRLCC Eugène Marquis (CRLCC)</contributor>
<contributor>ANSM, Agence Nationale de Sécurité du Médicament et des Produits de Santé</contributor>
<description>International audience</description>
<source>ISSN: 2045-2322</source>
<source>EISSN: 2045-2322</source>
<source>Scientific Reports</source>
<publisher>Nature Publishing Group</publisher>
<identifier>hal-01517095</identifier>
<identifier>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01517095</identifier>
<source>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01517095</source>
<source>Scientific Reports, Nature Publishing Group, 2017, 7, pp.44184. 〈10.1038/srep44184〉</source>
<identifier>DOI : 10.1038/srep44184</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1038/srep44184</relation>
<identifier>PUBMED : 28281692</identifier>
<relation>info:eu-repo/semantics/altIdentifier/pmid/28281692</relation>
<language>en</language>
<subject>[SDV.EE.SANT] Life Sciences [q-bio]/Ecology, environment/Health</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>Among pregnant women ibuprofen is one of the most frequently used pharmaceutical compounds with up to 28% reporting use. Regardless of this, it remains unknown whether ibuprofen could act as an endocrine disruptor as reported for fellow analgesics paracetamol and aspirin. To investigate this, we exposed human fetal testes (7-17 gestational weeks (GW)) to ibuprofen using ex vivo culture and xenograft systems. Ibuprofen suppressed testosterone and Leydig cell hormone INSL3 during culture of 8-9 GW fetal testes with concomitant reduction in expression of the steroidogenic enzymes CYP11A1, CYP17A1 and HSD17B3, and of INSL3. Testosterone was not suppressed in testes from fetuses younger than 8 GW, older than 10-12 GW, or in second trimester xenografted testes (14-17 GW). Ex vivo, ibuprofen also affected Sertoli cell by suppressing AMH production and mRNA expression of AMH, SOX9, DHH, and COL2A1. While PGE2 production was suppressed by ibuprofen, PGD2 production was not. Germ cell transcripts POU5F1, TFAP2C, LIN28A, ALPP and KIT were also reduced by ibuprofen. We conclude that, at concentrations relevant to human exposure and within a particular narrow â €' early window' of sensitivity within first trimester, ibuprofen causes direct endocrine disturbances in the human fetal testis and alteration of the germ cell biology. © The Author(s) 2017.</description>
<date>2017</date>
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