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<publisher>HAL CCSD</publisher>
<title lang=en>Impact of Hodgkin or non-Hodgkin lymphoma and their treatments on sperm aneuploidy: a prospective study by the French CECOS network.</title>
<creator>Martinez, Guillaume</creator>
<creator>Walschaerts, Marie</creator>
<creator>Le Mitouard, Marine</creator>
<creator>Borye, Remi</creator>
<creator>Thomas, Claire</creator>
<creator>Auger, Jacques</creator>
<creator>Berthaut, Isabelle</creator>
<creator>Brugnon, Florence</creator>
<creator>Daudin, Myriam</creator>
<creator>Moinard, Nathalie</creator>
<creator>Ravel, Célia</creator>
<creator>Saias, Jacqueline</creator>
<creator>Szerman, Ethel</creator>
<creator>Rives, Nathalie</creator>
<creator>Hennebicq, Sylviane</creator>
<creator>Bujan, Louis</creator>
<contributor>Centre d'Investigation Clinique - Innovation Technologique - INSERM - CHU de Grenoble (CIC-IT Grenoble (CIT803)) ; Université Joseph Fourier - Grenoble 1 (UJF) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Centre Hospitalier Universitaire de Grenoble</contributor>
<contributor>Université de Toulouse - Equipe de recherche en fertilité humaine EA 3694 (EA 3694) ; Université Paul Sabatier - Toulouse 3 (UPS)</contributor>
<contributor>Service d'Histologie-Embryologie, Biologie de la Reproduction (CECOS) ; Assistance publique - Hôpitaux de Paris (AP-HP) - CHU Cochin [AP-HP]</contributor>
<contributor>Histologie et biologie de la reproduction ; Université Pierre et Marie Curie - Paris 6 (UPMC) - Assistance publique - Hôpitaux de Paris (AP-HP)</contributor>
<contributor>Génétique, reproduction et développement (GReD) ; Centre National de la Recherche Scientifique (CNRS) - Institut National de la Santé et de la Recherche Médicale (INSERM) - IFR79 - Université d'Auvergne - Clermont-Ferrand I (UdA) - Université Blaise Pascal - Clermont-Ferrand 2 (UBP)</contributor>
<contributor>Laboratoire BDR CECOS - FIV AMP ; CHU Estaing [Clermont-Ferrand]</contributor>
<contributor>Groupe de recherche en fertilité humaine (EA3694) ; Université Paul Sabatier - Toulouse 3 (UPS) - CECOS Midi-pyrénées</contributor>
<contributor>Institut de Génétique et Développement de Rennes (IGDR) ; Université de Rennes 1 (UR1) - Centre National de la Recherche Scientifique (CNRS) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )</contributor>
<contributor>Institut de recherche, santé, environnement et travail [Rennes] (Irset) ; Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )</contributor>
<contributor>Hôpital de la Conception [CHU - APHM] (LA CONCEPTION )</contributor>
<contributor>CHU Côte de Nacre</contributor>
<contributor>Université de Rouen Normandie (URN) ; Normandie Université (NU)</contributor>
<contributor>Université Joseph Fourier - Grenoble 1 (UJF)</contributor>
<contributor>AGeing and IMagery (AGIM) ; Université Pierre Mendès France - Grenoble 2 (UPMF) - Université Joseph Fourier - Grenoble 1 (UJF) - École pratique des hautes études (EPHE) - Centre National de la Recherche Scientifique (CNRS)</contributor>
<contributor>Laboratoire d’Aide à la Procréation, Département de Génétique et Procréation (CECOS) ; Hôpital Couple Enfant de Grenoble - CHU de Grenoble</contributor>
<contributor>CECOS Midi-Pyrénées, centre de sterilité masculine et équipe d'accueil Fertilité Humaine ; Hôpital Paule de Viguier - EA 3694</contributor>
<description>International audience</description>
<source>Fertility and sterility</source>
<identifier>hal-01477204</identifier>
<identifier>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01477204</identifier>
<source>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01477204</source>
<source>Fertility and sterility, 2017, 107 (2), pp.341-350.e5. 〈10.1016/j.fertnstert.2016.10.001〉</source>
<identifier>DOI : 10.1016/j.fertnstert.2016.10.001</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1016/j.fertnstert.2016.10.001</relation>
<identifier>PUBMED : 27810161</identifier>
<relation>info:eu-repo/semantics/altIdentifier/pmid/27810161</relation>
<language>en</language>
<subject>[SDV.EE] Life Sciences [q-bio]/Ecology, environment</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>OBJECTIVE: To assess sperm production and aneuploidy in Hodgkin lymphoma (HL) and non-Hodgkin lymphoma (NHL) before and after treatments. DESIGN: Multicenter, prospective, longitudinal study of lymphoma patients analyzed before treatment and after 3, 6, 12, and 24 months. SETTING: University hospitals. PATIENT(S): Forty-five HL and 13 NHL patients were investigated before and after treatment. Treatment regimens were classified in two groups: ABVD (doxorubicin, bleomycin, vinblastine, dacarbazine) with or without (+/-) radiotherapy, and CHOP (doxorubicin, cyclophosphamide, vincristine, prednisone)/MOPP-ABV (mechlorethamine, oncovin, procarbazine, prednisone-doxorubicin, bleomycin, vinblastine). A control group of 29 healthy men was also studied. INTERVENTION(S): Semen analyses and aneuploidy study by FISH were performed at each time point. MAIN OUTCOME MEASURE(S): Comparison of mean sperm characteristics and percentage of sperm aneuploidy rates before and after treatment. RESULT(S): Before treatment, HL and NHL men had altered semen characteristics and higher sperm aneuploidy rates (median 0.76 [interquartile range 0.56-0.64]) than the control group (0.54 [0.46-0.74]). After treatment, sperm production was significantly lowered 3 and 6 months after ABVD +/- radiotherapy or CHOP/MOPP-ABV. After ABVD +/- radiotherapy, the aneuploidy rate increased significantly only at 3 months, and values obtained 1 or 2 years later were lower than pretreatment values. In contrast, in the CHOP/MOPP-ABV treatment group, semen characteristics and aneuploidy rate did not return to normal levels until 2 years after treatment. CONCLUSION(S): Lymphoma itself has consequences on sperm aneuploidy frequency before treatment. Moreover, lymphoma treatments have deleterious effects on sperm chromosomes related to treatment type and time since treatment. Patient counseling is essential concerning the transient but significant sperm aneuploidy induced by lymphoma and its treatments.</description>
<date>2017</date>
</dc>
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