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<title lang=en>IL-33 and HMGB1 alarmins: sensors of cellular death and their involvement in liver pathology.</title>
<creator>Arshad, Muhammad I</creator>
<creator>Piquet-Pellorce, Claire</creator>
<creator>Samson, Michel</creator>
<contributor>Institut de recherche, santé, environnement et travail [Rennes] (Irset) ; Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )</contributor>
<contributor>INSERM; the Ministère de l'Education Nationale de la Recherche et de la Technologie; University of Rennes 1; Région Bretagne; 'Ligue contre le cancer'; 'UMS 3480- BioSIT (plateform H2P2)</contributor>
<description>International audience</description>
<source>ISSN: 1478-3223</source>
<source>EISSN: 1478-3231</source>
<source>Liver International</source>
<publisher>Wiley-Blackwell</publisher>
<identifier>hal-00874209</identifier>
<identifier>https://hal.archives-ouvertes.fr/hal-00874209</identifier>
<source>https://hal.archives-ouvertes.fr/hal-00874209</source>
<source>Liver International, Wiley-Blackwell, 2012, 32 (8), pp.1200-10. 〈10.1111/j.1478-3231.2012.02802.x〉</source>
<identifier>DOI : 10.1111/j.1478-3231.2012.02802.x</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1111/j.1478-3231.2012.02802.x</relation>
<identifier>PUBMED : 22530772</identifier>
<relation>info:eu-repo/semantics/altIdentifier/pmid/22530772</relation>
<language>en</language>
<subject lang=en>alarmin</subject>
<subject lang=en>cytokine</subject>
<subject lang=en>hepatitis</subject>
<subject lang=en>HMGB1</subject>
<subject lang=en>IL-33</subject>
<subject>[SDV.MHEP.HEG] Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>'Alarmins' are a group of proteins or molecules that are released from cells during cellular demise to alert the host immune system. Two of them, Interleukin-33 (IL-33) and high-mobility group box-1 (HMGB1), share many similarities of cellular localization, functions and involvement in various inflammatory pathologies including hepatitis. The expressions of IL-33 and HMGB1, and their receptors ST2 and receptor for advanced glycation end products (RAGE), are substantially up-regulated during acute and chronic hepatitis. Recent data evidence a possible protective role of IL-33/ST2 axis during liver injury. A contrast in expression of IL-33 and HMGB1 alarmins were associated with type of hepatocellular death mediated by immune cells or hepato-toxic agents. The massive release of active form of IL-33 from hepatocytes may affect the recruitment and activation of its ST2-positive target immune cells in the liver to confer its alarmin functions. This review highlights the emerging roles of alarmin proteins in various liver pathologies, by focusing on classical HMGB1 and a newly discovered alarmin, the IL-33.</description>
<date>2012-09</date>
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