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<title lang=en>AhR- and NF-κB-dependent induction of interleukin-6 by co-exposure to the environmental contaminant benzanthracene and the cytokine tumor necrosis factor-α in human mammary MCF-7 cells.</title>
<creator>Kolasa, Elise</creator>
<creator>Houlbert, Noemie</creator>
<creator>Balaguer, Patrick</creator>
<creator>FARDEL, Olivier</creator>
<contributor>Contaminants Chimiques, immunité et Inflammation ; Institut de recherche, santé, environnement et travail [Rennes] (Irset) ; Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ) - Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )</contributor>
<contributor>Institut de recherche en cancérologie de Montpellier (IRCM) ; Université Montpellier 1 (UM1) - CRLCC Val d'Aurelle - Paul Lamarque - Institut National de la Santé et de la Recherche Médicale (INSERM) - Université de Montpellier (UM)</contributor>
<contributor>Contaminants Chimiques, immunité et Inflammation ; Institut de recherche, santé, environnement et travail [Rennes] (Irset) ; Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ) - Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ) - Pôle Biologie ; Hôpital Pontchaillou - CHU Pontchaillou [Rennes] - Hôpital Pontchaillou - CHU Pontchaillou [Rennes]</contributor>
<description>International audience</description>
<source>ISSN: 0009-2797</source>
<source>Chemico-Biological Interactions</source>
<publisher>Elsevier</publisher>
<identifier>inserm-00818896</identifier>
<identifier>http://www.hal.inserm.fr/inserm-00818896</identifier>
<source>http://www.hal.inserm.fr/inserm-00818896</source>
<source>Chemico-Biological Interactions, Elsevier, 2013, 203 (2), pp.391-400. 〈10.1016/j.cbi.2013.01.005〉</source>
<identifier>DOI : 10.1016/j.cbi.2013.01.005</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1016/j.cbi.2013.01.005</relation>
<identifier>PUBMED : 23396138</identifier>
<relation>info:eu-repo/semantics/altIdentifier/pmid/23396138</relation>
<language>en</language>
<subject lang=en>Polycyclic aromatic hydrocarbon</subject>
<subject lang=en>Tumor necrosis factor-α</subject>
<subject lang=en>Interleukin-6</subject>
<subject lang=en>Aryl hydrocarbon receptor</subject>
<subject lang=en>NF-κB</subject>
<subject lang=en>Inflammation</subject>
<subject>[SDV.BBM] Life Sciences [q-bio]/Biochemistry, Molecular Biology</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>Co-exposure to environmental polycyclic aromatic hydrocarbons (PAHs) and interleukin (IL)-1β induces expression of the tumor-promoting cytokine IL-6 in cancer cells. The present study was designed to determine whether such an IL-6 up-regulation also occurs in response to co-treatment by PAHs and tumor necrosis factor (TNF)-α, an inflammatory cytokine commonly found in tumor microenvironment. Co-exposure to the prototypical PAH benzanthracene (BZA) and TNF-α was found to markedly induce mRNA expression and secretion of IL-6 in human breast cancer cells MCF-7, whereas exposure to either BZA or TNF-α alone was without significant effect. Co-treatment by BZA and TNF-α-containing conditioned media from human inflammatory macrophages similarly up-regulated IL-6 expression in MCF-7 cells. BZA/TNF-α-mediated IL-6 induction in MCF-7 cells was counteracted by silencing aryl hydrocarbon receptor (AhR), known to mediates most of PAH effects. IL-6 up-regulation was moreover associated with NF-κB activation and was abolished by using chemical NF-κB inhibitors or knocking-down expression of the p65/RelA NF-κB subunit. Taken together, these data indicate that co-exposure to BZA/TNF-α induces IL-6 expression by AhR- and NF-κB-dependent pathways in MCF-7 cancer cells. This regulation of IL-6 by environmental PAHs, that is dependent of inflammatory cytokine microenvironment, may contribute to the well-known carcinogenic properties of these organic pollutants.</description>
<date>2013-04-25</date>
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