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<identifier>oai:HAL:pasteur-00931155v1</identifier>
<datestamp>2014-01-15</datestamp>
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<metadata><dc>
<publisher>HAL CCSD</publisher>
<title lang=en>Antimycobacterial activity of chemically defined natural substances from the Caribbean flora in Guadeloupe.</title>
<creator>Rastogi, N.</creator>
<creator>Abaul, J.</creator>
<creator>Goh, K. S.</creator>
<creator>Devallois, A.</creator>
<creator>Philogène, E.</creator>
<creator>Bourgeois, P.</creator>
<contributor>Institut Pasteur de la Guadeloupe ; Réseau International des Instituts Pasteur - Institut Pasteur de la Guadeloupe</contributor>
<contributor>Faculté des Sciences Exactes et Naturelles ; Université des Antilles et de la Guyane (UAG)</contributor>
<contributor>This research was supported primarily through the Délégation Général au Réseau International des Instituts Pasteur et Instituts Associeés, Institut Pasteur, Paris, and Fondation Française Raoul Follereau, Paris, France</contributor>
<description>International audience</description>
<source>FEMS Immunology and Medical Microbiology</source>
<publisher>Wiley-Blackwell: No OnlineOpen</publisher>
<identifier>pasteur-00931155</identifier>
<identifier>https://hal-riip.archives-ouvertes.fr/pasteur-00931155</identifier>
<source>https://hal-riip.archives-ouvertes.fr/pasteur-00931155</source>
<source>FEMS Immunology and Medical Microbiology, Wiley-Blackwell: No OnlineOpen, 1998, 20 (4), pp.267-273</source>
<identifier>PUBMED : 9626931</identifier>
<language>en</language>
<subject>[SDV.MP.BAC] Life Sciences/Microbiology and Parasitology/Bacteriology</subject>
<type>Journal articles</type>
<description lang=en>Eight chemically defined, naturally occurring compounds were extracted from the tropical flora of the Caribbean island of Guadeloupe: pilocarpine, an alkaloid from Pilocarpus racemosus; heraclenol and isomeranzin, coumarins from Triphasia trifolia; lochnerin, an indole alkaloid from Rauwolfia biauriculata; ibogaine and voacangine, indole alkaloids from Tabernaemontana citrifolia; texalin, an oxazole from Amyris elemifera; and canellal, a sesquiterpene dialdehyde from Canella winterana. An essential oil fraction from Canella winterana was also tested. The antimycobacterial activity of these substances was tested against Mycobacterium tuberculosis, M. avium and M. kansasii using the Middlebrook 7H11 agar medium, the Bactec 460-TB radiometric methodology, and determination of bacterial viable counts. Three compounds, namely ibogaine, voacangine and texalin, showed antimycobacterial activity. Investigations on the structure-modification and structure-activity relationships of these compounds may help determine new targets for future drug development.</description>
<date>1998-04</date>
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