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<title lang=en>Assuring safety without animal testing: the case for the human testis in vitro.</title>
<creator>Chapin, Robert E</creator>
<creator>Boekelheide, Kim</creator>
<creator>Cortvrindt, Rita</creator>
<creator>Van Duursen, Majorie B M</creator>
<creator>Gant, Tim</creator>
<creator>Jegou, Bernard</creator>
<creator>Marczylo, Emma</creator>
<creator>Van Pelt, Ans M M</creator>
<creator>Post, Janine N</creator>
<creator>Roelofs, Maarke J E</creator>
<creator>Schlatt, Stefan</creator>
<creator>Teerds, Katja J</creator>
<creator>Toppari, Jorma</creator>
<creator>Piersma, Aldert H</creator>
<contributor>Environnement viral et chimique & reproduction ; Institut de recherche, santé, environnement et travail [Rennes] (Irset) ; Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ) - Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )</contributor>
<contributor>Institute of Biomedicine/Physiology ; Institute of Biomedicine/Physiology</contributor>
<contributor>"Proefdiervrij" (the Dutch Society for the Replacement of Animal Testing (dsRAT)); the ASAT Foundation.</contributor>
<description>International audience</description>
<source>ISSN: 0890-6238</source>
<source>Reproductive Toxicology</source>
<publisher>Elsevier</publisher>
<identifier>hal-00876979</identifier>
<identifier>https://hal.archives-ouvertes.fr/hal-00876979</identifier>
<source>https://hal.archives-ouvertes.fr/hal-00876979</source>
<source>Reproductive Toxicology, Elsevier, 2013, 39, pp.63-8. 〈10.1016/j.reprotox.2013.04.004〉</source>
<identifier>DOI : 10.1016/j.reprotox.2013.04.004</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1016/j.reprotox.2013.04.004</relation>
<identifier>PUBMED : 23612449</identifier>
<relation>info:eu-repo/semantics/altIdentifier/pmid/23612449</relation>
<language>en</language>
<subject lang=en>Human testis</subject>
<subject lang=en>Alternatives to animal testing</subject>
<subject lang=en>Tissue engineering</subject>
<subject lang=en>Spermatogenesis</subject>
<subject lang=en>3D cell culture</subject>
<subject lang=en>Leydig cell</subject>
<subject lang=en>Sertoli cell</subject>
<subject lang=en>Male fertility</subject>
<subject>[SDV.TOX] Life Sciences [q-bio]/Toxicology</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>From 15 to 17 June 2011, a dedicated workshop was held on the subject of in vitro models for mammalian spermatogenesis and their applications in toxicological hazard and risk assessment. The workshop was sponsored by the Dutch ASAT initiative (Assuring Safety without Animal Testing), which aims at promoting innovative approaches toward toxicological hazard and risk assessment on the basis of human and in vitro data, and replacement of animal studies. Participants addressed the state of the art regarding human and animal evidence for compound mediated testicular toxicity, reviewed existing alternative assay models, and brainstormed about future approaches, specifically considering tissue engineering. The workshop recognized the specific complexity of testicular function exemplified by dedicated cell types with distinct functionalities, as well as different cell compartments in terms of microenvironment and extracellular matrix components. This complexity hampers quick results in the realm of alternative models. Nevertheless, progress has been achieved in recent years, and innovative approaches in tissue engineering may open new avenues for mimicking testicular function in vitro. Although feasible, significant investment is deemed essential to be able to bring new ideas into practice in the laboratory. For the advancement of in vitro testicular toxicity testing, one of the most sensitive end points in regulatory reproductive toxicity testing, such an investment is highly desirable.</description>
<date>2013-08</date>
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