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<title lang=en>Acute varicella zoster encephalitis without evidence of primary vasculopathy in a case-series of 20 patients.</title>
<creator>De Broucker, T.</creator>
<creator>Mailles, Alexandra</creator>
<creator>Chabrier, Stéphane</creator>
<creator>Morand, Patrice</creator>
<creator>Stahl, Jean-Paul</creator>
<creator>Michelet, Christian</creator>
<contributor>Département des maladies infectieuses ; Institut de Veille Sanitaire (INVS)</contributor>
<contributor>service de médecine physique et réadaptation pédiatrique ; Institut National de la Santé et de la Recherche Médicale (INSERM) - Hôpital Bellevue - CHU de Saint-Etienne</contributor>
<contributor>Laboratoire de Virologie moléculaire et structurale ; CHU Grenoble</contributor>
<contributor>Service de maladies infectieuses et tropicales ; Université Joseph Fourier - Grenoble 1 (UJF) - CHU Grenoble</contributor>
<contributor>Institut de recherche, santé, environnement et travail [Rennes] (Irset) ; Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )</contributor>
<description>International audience</description>
<source>ISSN: 1198-743X</source>
<source>EISSN: 1469-0691</source>
<source>Clinical Microbiology and Infection</source>
<publisher>Wiley</publisher>
<identifier>hal-00875232</identifier>
<identifier>https://hal.archives-ouvertes.fr/hal-00875232</identifier>
<source>https://hal.archives-ouvertes.fr/hal-00875232</source>
<source>Clinical Microbiology and Infection, Wiley, 2012, 18 (8), pp.808-19. 〈10.1111/j.1469-0691.2011.03705.x〉</source>
<identifier>PUBMED : 22085160</identifier>
<relation>info:eu-repo/semantics/altIdentifier/pmid/22085160</relation>
<identifier>DOI : 10.1111/j.1469-0691.2011.03705.x</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1111/j.1469-0691.2011.03705.x</relation>
<language>en</language>
<subject lang=it>Encephalitis</subject>
<subject lang=it>imaging</subject>
<subject lang=it>varicella zoster virus</subject>
<subject lang=it>vasculopathy</subject>
<subject>[SDV.MP] Life Sciences [q-bio]/Microbiology and Parasitology</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>Varicella zoster virus (VZV) is a leading cause of acute viral encephalitis but little is known about its clinical, biological and imaging features. Furthermore, the most favourable treatment regimen has not been determined. We studied a prospective cohort of 20 HIV-negative patients presenting with acute VZV encephalitis caused by primary infection or reactivation. VZV was identified in 16 of 20 cases by PCR detection of the DNA in the cerebrospinal fluid. The four remaining cases occurred during or soon after a VZV rash. The median age of the 17 adults was 76 (19-86) years; the three other patients were children (0.5-5 years). Three patients were immunocompromised. Nine adult patients presented with a rash. Eighteen patients presented with fever and an acute encephalitic syndrome: diffuse brain dysfunction, focal neurological signs, seizures and cranial nerve palsies. Three patients presented with either ventricular or subdural haemorrhage, one with myelitis, and one with asymptomatic stenosis of the middle cerebral artery. The imaging was either normal or revealed non-specific abnormalities such as cortical atrophy but no evidence of stroke. All patients were given acyclovir at various dosages and durations but the case fatality rate remained high (15%) and sequelae were frequently observed either at discharge or at follow-up 3 years later.</description>
<contributor>Steering Committee and Investigators Group</contributor>
<date>2012-08</date>
</dc>
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