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<title lang=en>Associations of Plasma Concentrations of Dichlorodiphenyldichloroethylene and Polychlorinated Biphenyls with Prostate Cancer: A Case-Control Study in Guadeloupe (French West Indies).</title>
<creator>Emeville, Elise</creator>
<creator>Giusti, Arnaud</creator>
<creator>Coumoul, Xavier</creator>
<creator>Thomé, Jean-Pierre</creator>
<creator>Blanchet, Pascal</creator>
<creator>Multigner, Luc</creator>
<contributor>Institut de recherche, santé, environnement et travail [Rennes] (Irset) ; Université d'Angers (UA) - Université des Antilles et de la Guyane (UAG) - Université de Rennes 1 (UR1) - École des Hautes Études en Santé Publique [EHESP] (EHESP) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )</contributor>
<contributor>Center for Analytical Research and Technology ; Université de Liège</contributor>
<contributor>Physiologie Cellulaire des Regulations Hormonales, Nutritionnelles et Pharmacologiques ; Université Paris Descartes - Paris 5 (UPD5) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Centre National de la Recherche Scientifique (CNRS)</contributor>
<description>International audience</description>
<source>ISSN: 0091-6765</source>
<source>EISSN: 1552-9924</source>
<source>Environmental Health Perspectives</source>
<publisher>National Institute of Environmental Health Sciences (NIEHS)</publisher>
<publisher>National Institute of Environmental Health Sciences</publisher>
<identifier>hal-01118553</identifier>
<identifier>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01118553</identifier>
<source>https://hal-univ-rennes1.archives-ouvertes.fr/hal-01118553</source>
<source>Environmental Health Perspectives, National Institute of Environmental Health Sciences, 2014, 123 (4), pp.317. 〈10.1289/ehp.1408407〉</source>
<identifier>DOI : 10.1289/ehp.1408407</identifier>
<relation>info:eu-repo/semantics/altIdentifier/doi/10.1289/ehp.1408407</relation>
<identifier>PUBMED : 25493337</identifier>
<relation>info:eu-repo/semantics/altIdentifier/pmid/25493337</relation>
<language>en</language>
<subject>[SDV] Life Sciences [q-bio]</subject>
<type>info:eu-repo/semantics/article</type>
<type>Journal articles</type>
<description lang=en>Long-term exposure to persistent pollutants with hormonal properties (endocrine-disrupting chemicals, EDCs) may contribute to the risk of prostate cancer (PCa). However, epidemiological evidence remains limited. We investigated the relationship between PCa and plasma concentrations of universally widespread pollutants, in particular p,p'-dichlorodiphenyl dichloroethene (DDE) and the non-dioxin like polychlorinated biphenyl congener 153 (PCB153). We evaluated before treatment 576 men with newly diagnosed PCa and 655 controls in Guadeloupe (French West Indies). Exposure was analyzed according to case-control status. Associations were assessed by unconditional logistic regression analysis, controlling for confounding factors. Missing data were handled by multiple imputation. We estimated a significant positive association between DDE and PCa (adjusted odds ratio [OR] 1.53; 95% CI 1.02, 2.30 for the highest versus lowest quintile of exposure; PTrend = 0.01). PCB153 was inversely associated with PCa (OR 0.30; 95% CI 0.19, 0.47 for the highest versus lowest quintile of exposure values; PTrend < 0.001). Also, PCB153 was more strongly associated to low-grade than high grade PCa. Associations of PCa with DDE and PCB153 were in opposite directions. This may reflect differences in the mechanisms of action of these EDCs, and although our findings need to be replicated in other populations, they are consistent with complex effects of EDCs on human health.</description>
<date>2014-11-21</date>
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